Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Syst Rev. 2023 Apr 12;12(1):65. doi: 10.1186/s13643-023-02228-y.
We aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to investigate the effects of rice bran supplementation on serum lipid profile levels.
We searched PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar using related keywords. Published RCTs exploring the effects of rice bran consumption on lipid profile were searched up to June 2022. Evidence certainty was assessed on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The data were pooled using a random-effects model and reported as weighted mean difference (WMD) and 95% confidence interval (CI) for each outcome.
Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of triglyceride (WMD: -11.38 mg/dl; 95% CI: -27.73, 4.96; P = 0.17), total cholesterol (WMD: -0.68 mg/dl; 95% CI: -7.25, 5.88; P = 0.834), low-density lipoprotein cholesterol (WMD: -1.68 mg/dl; 95% CI: -8.46, 5.09; P = 0.627) and high-density lipoprotein cholesterol (WMD: 0.16 mg/dl; 95% CI: -1.52, 1.85; P = 0.848) compared to control group.
Our meta-analysis suggests that rice bran supplementation has no significant effects on serum levels of lipid profile components. However, larger studies with longer durations and improved methodological quality are needed before firm conclusions can be reached.
本研究旨在进行系统评价和荟萃分析，以评估米糠补充剂对血清脂质谱水平的影响。
我们检索了 PubMed/Medline、Scopus、ISI Web of Science 和 Google Scholar 数据库，使用相关关键词进行检索。检索截至 2022 年 6 月公开发表的探讨米糠消费对血脂谱影响的随机对照试验。根据推荐评估、制定与评价（GRADE）方法评估证据确定性。使用随机效应模型对数据进行合并，并报告每个结局的加权均数差（WMD）和 95%置信区间（CI）。
荟萃分析纳入了 8 项 RCT（包含 11 个效应量），结果显示，米糠补充剂对血清甘油三酯水平（WMD：-11.38 mg/dl；95%CI：-27.73, 4.96；P=0.17）、总胆固醇水平（WMD：-0.68 mg/dl；95%CI：-7.25, 5.88；P=0.834）、低密度脂蛋白胆固醇水平（WMD：-1.68 mg/dl；95%CI：-8.46, 5.09；P=0.627）和高密度脂蛋白胆固醇水平（WMD：0.16 mg/dl；95%CI：-1.52, 1.85；P=0.848）均无显著影响，与对照组相比。
我们的荟萃分析表明，米糠补充剂对血清脂质谱成分水平无显著影响。然而，需要进行更长时间和方法学质量更高的大型研究，才能得出更确定的结论。
