Department of Periodontics, School of Dentistry, University of Granada, Granada, Spain.
Department of Preventive and Community Dentistry, University of Granada, Granada, Spain.
Sci Rep. 2023 Apr 18;13(1):6294. doi: 10.1038/s41598-023-33521-4.
To determine the effects on gingival bleeding, dental biofilm, and salivary flow and pH in patients with gingivitis of using toothpaste with extra-virgin olive oil (EVOO), xylitol, and betaine in comparison to a placebo or commercial toothpaste. This controlled, double blinded, and multicenter randomized clinical trial included patients with gingivitis randomly assigned to one of three groups: test group (EVOO, xylitol, and betaine toothpaste), control group 1 (placebo toothpaste), or control group 2 (commercial toothpaste). Percentage supragingival biofilm and gingival bleeding were evaluated at baseline (T0), 2 months (T2), and 4 months (T4), measuring non-stimulated salivary flow and salivary pH. Comparisons were performed between and within groups. The final study sample comprised 20 in the test group, 21 in control group 1, and 20 in control group 2. In comparison to control group 1, the test group showed significantly greater decreases in gingival bleeding between T4 and T0 (p = 0.02) and in biofilm between T2 and T0 (p = 0.02) and between T4 and T0 (p = 0.01). In the test group, salivary flow significantly increased between T2 and T0 (p = 0.01), while pH alkalization was significantly greater between T4 and T0 versus control group 2 (p = 0.01) and close-to-significantly greater versus control group 1 (p = 0.06). The toothpaste with EVOO, xylitol, and betaine obtained the best outcomes in patients with gingivitis, who showed reductions in gingival bleeding and supragingival biofilm and an increase in pH at 4 months in comparison to a commercial toothpaste.
为了确定在牙龈炎患者中使用含有特级初榨橄榄油（EVOO）、木糖醇和甜菜碱的牙膏相对于安慰剂或商业牙膏对牙龈出血、牙菌斑生物膜和唾液流量及 pH 的影响。这项对照、双盲、多中心随机临床试验纳入了随机分配到三组的牙龈炎患者：实验组（EVOO、木糖醇和甜菜碱牙膏）、对照组 1（安慰剂牙膏）或对照组 2（商业牙膏）。在基线（T0）、2 个月（T2）和 4 个月（T4）时评估龈上菌斑生物膜和牙龈出血的百分比，测量非刺激性唾液流量和唾液 pH 值。对组间和组内进行了比较。最终研究样本包括实验组 20 例、对照组 1 21 例和对照组 2 20 例。与对照组 1 相比，实验组在 T4 与 T0 之间（p=0.02）和 T2 与 T0 之间（p=0.02）以及 T4 与 T0 之间（p=0.01）的牙龈出血显著减少。在实验组中，唾液流量在 T2 与 T0 之间显著增加（p=0.01），而在 T4 与 T0 之间与对照组 2 相比（p=0.01）和接近对照组 1 相比（p=0.06）pH 值的碱化显著增加。含有特级初榨橄榄油、木糖醇和甜菜碱的牙膏在牙龈炎患者中获得了最佳效果，与商业牙膏相比，患者在 4 个月时牙龈出血和龈上菌斑生物膜减少，pH 值增加。
