Hisamuddin Ahmad Safiyyu'd-Din Bin, Naomi Ruth, Bin Manan Khairul Aiman, Bahari Hasnah, Yazid Muhammad Dain, Othman Fezah, Embong Hashim, Hadizah Jumidil Siti, Hussain Mohd Khairi, Zakaria Zainul Amiruddin
Borneo Research on Algesia, Inflammation and Neurodegeneration (BRAIN) Group, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
Front Pharmacol. 2023 Apr 3;14:1132087. doi: 10.3389/fphar.2023.1132087. eCollection 2023.
This study assessed the toxicity of lutein-rich purple sweet potato leaf (PSPL) extract in male Sprague-Dawley rats. A total of 54 adult male Sprague-Dawley rats were used. For the acute toxicity study, three rats in the acute control group were fed 2,000 mg/kg of PSPL for 14 days. The subacute toxicity study included six rats each in four groups administered 50, 250, 500, or 1,000 mg/kg for 28 days and observed for further 14 days without treatment in the subacute control and subacute satellite groups. Changes in body weight; blood biochemistry; hematological parameters; relative organ weight; and histological sections of the heart, kidney, liver, pancreas, aorta, and retina were observed for signs of toxicity. The gradual increase in weekly body weight, normal level full blood count, normal liver and kidney profile, relative organ weight, and histological sections of all stained organ tissue in the treated group compared with the acute, subacute, and satellite control groups demonstrated the absence of signs of toxicity. Lutein-rich PSPL extract shows no signs of toxicity up to 2,000 mg/kg/day.
本研究评估了富含叶黄素的紫甘薯叶（PSPL）提取物对雄性Sprague-Dawley大鼠的毒性。总共使用了54只成年雄性Sprague-Dawley大鼠。在急性毒性研究中，急性对照组的三只大鼠连续14天喂食2000mg/kg的PSPL。亚急性毒性研究包括四组，每组六只大鼠，分别给予50、250、500或1000mg/kg的剂量，持续28天，在亚急性对照组和亚急性卫星组中，在未进行处理的情况下再观察14天。观察体重变化、血液生化指标、血液学参数、相对器官重量以及心脏、肾脏、肝脏、胰腺、主动脉和视网膜的组织切片，以寻找毒性迹象。与急性、亚急性和卫星对照组相比，治疗组每周体重逐渐增加、全血细胞计数正常、肝肾功能正常、相对器官重量正常以及所有染色器官组织的组织切片正常，表明没有毒性迹象。富含叶黄素的PSPL提取物在高达2000mg/kg/天的剂量下未显示出毒性迹象。
