1 College of Allied Health Professionals, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
2 Department of Eastern Medicine and Surgery, Directorate of Medical Sciences, Government College University Faisalabad, Faisalabad, Pakistan.
Int J Immunopathol Pharmacol. 2018 Mar-Dec;32:2058738418814678. doi: 10.1177/2058738418814678.
Different allopathic drugs are being used for the treatment of diabetes mellitus but more emphasis are being placed on the use of medicinal plants, herbs, and natural extracts of fruits and vegetables due to their easy availability, easy consummation with low cost, and with no well-reported side effects. White skinned sweet potato (WSSP; Ipomoea batatas L.) peel-off was selected to find out its antidiabetic potential as well as to explore the effects on selected biochemical parameters in diabetes-induced Wistar rats. In young (3-4 months) and old (up to 1 year) diabetic Wistar rats, it was found that WSSP ( I. batatas L.) peel-off significantly ( P < 0.05) decreased blood glucose level, protein glycation level, total cholesterol, triglycerides, and low-density lipoprotein (LDL)-cholesterol. A significant ( P < 0.05) increase in high-density lipoprotein (HDL)-cholesterol level after treatment was also reported. Furthermore, it was also found that WSSP peel-off also had beneficial effects on total protein concentration, albumin, globulin, and liver enzymes (serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT)). It might be concluded that antidiabetic potential of WSSP extract is due to the presence of bioactive compounds like glycoprotein, anthocyanins, alkaloids, and flavonoids, which act as insulin-like molecules or insulin secretagogues constituents in sweet potatoes peel-off and these antidiabetic proteins were extracted out in more concentration in methanol due to its organic nature. Further research is needed to purify and quantify the antidiabetic components responsible for antidiabetic effects of WSSP and it should be available in compact dose form for the treatment of diabetic patients.
不同的西药被用于治疗糖尿病，但由于药用植物、草药和水果、蔬菜的天然提取物易于获取、成本低且不易报告副作用，因此更多地强调使用这些植物、草药和天然提取物。我们选择白皮番薯（Ipomoea batatas L.）皮来研究其抗糖尿病的潜力，并探索其对糖尿病诱导的 Wistar 大鼠选定生化参数的影响。在年轻（3-4 个月）和年老（长达 1 年）的糖尿病 Wistar 大鼠中，发现白皮番薯（Ipomoea batatas L.）皮显著（P<0.05）降低了血糖水平、蛋白质糖化水平、总胆固醇、甘油三酯和低密度脂蛋白（LDL）-胆固醇。治疗后高密度脂蛋白（HDL）-胆固醇水平也显著升高（P<0.05）。此外，还发现白皮番薯皮对总蛋白浓度、白蛋白、球蛋白和肝酶（血清谷氨酸草酰乙酸转氨酶（SGOT）和血清谷氨酸丙酮酸转氨酶（SGPT））也有有益影响。可以得出结论，白皮番薯提取物的抗糖尿病潜力是由于其存在生物活性化合物，如糖蛋白、花青素、生物碱和类黄酮，这些化合物在番薯皮中作为胰岛素样分子或胰岛素分泌激动剂成分，而甲醇由于其有机性质，可以更集中地提取这些抗糖尿病蛋白。需要进一步研究以纯化和定量负责白皮番薯抗糖尿病作用的抗糖尿病成分，并以更方便患者使用的浓缩剂量形式提供给糖尿病患者。
