新型抗生素萘并放线菌素的结构

Structures of new antibiotics napyradiomycins.

作者信息

Shiomi K, Nakamura H, Iinuma H, Naganawa H, Isshiki K, Takeuchi T, Umezawa H, Iitaka Y

出版信息

J Antibiot (Tokyo). 1986 Apr;39(4):494-501. doi: 10.7164/antibiotics.39.494.

DOI:10.7164/antibiotics.39.494

Abstract

Structures of novel antibiotics, napyradiomycins A, B1, B2, B3, C1 and C2 were determined. By X-ray crystallography, napyradiomycin B2 was determined to be (3R,10aR)-3-chloro-10a-[[(1R,3S)-3-chloro-2, 2-dimethyl-6-methylenecyclohexyl]methyl]-3,10a-dihydro-6,8-dihydro xy-2, 2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione. The structures of other napyradiomycins were elucidated by NMR studies. Napyradiomycins C1 and C2 have unique structures which contain 14-membered ring cyclized by carbon-carbon bond.

摘要

确定了新型抗生素纳普拉霉素A、B1、B2、B3、C1和C2的结构。通过X射线晶体学确定，纳普拉霉素B2为(3R,10aR)-3-氯-10a-[[(1R,3S)-3-氯-2,2-二甲基-6-亚甲基环己基]甲基]-3,10a-二氢-6,8-二羟基-2,2-二甲基-2H-萘并[2,3-b]吡喃-5,10-二酮。通过核磁共振研究阐明了其他纳普拉霉素的结构。纳普拉霉素C1和C2具有独特的结构，其包含通过碳-碳键环化的14元环。