Pisani Anna, Paciello Fabiola, Montuoro Raffaele, Rolesi Rolando, Galli Jacopo, Fetoni Anna Rita
Department of Otolaryngology Head and Neck Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Department of Neuroscience, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Life (Basel). 2023 Apr 17;13(4):1035. doi: 10.3390/life13041035.
Cochlear redox unbalance is the main mechanism of damage involved in the pathogenesis of noise-induced-hearing loss. Indeed, the increased free radical production, in conjunction with a reduced efficacy of the endogenous antioxidant system, plays a key role in cochlear damage induced by noise exposure. For this reason, several studies focused on the possibility to use exogenous antioxidant to prevent or attenuate noise-induce injury. Thus, several antioxidant molecules, alone or in combination with other compounds, have been tested in both experimental and clinical settings. In our findings, we tested the protective effects of several antioxidant enzymes, spanning from organic compounds to natural compounds, such as nutraceuticals of polyphenols. In this review, we summarize and discuss the strengths and weaknesses of antioxidant supplementation focusing on polyphenols, Q-Ter, the soluble form of CoQ10, Vitamin E and N-acetil-cysteine, which showed great otoprotective effects in different animal models of noise induced hearing loss and which has been proposed in clinical trials.
耳蜗氧化还原失衡是噪声性听力损失发病机制中损伤的主要机制。事实上，自由基产生增加，再加上内源性抗氧化系统功效降低，在噪声暴露引起的耳蜗损伤中起关键作用。因此，多项研究聚焦于使用外源性抗氧化剂预防或减轻噪声诱导损伤的可能性。于是，几种抗氧化分子单独或与其他化合物联合，已在实验和临床环境中进行了测试。在我们的研究结果中，我们测试了几种抗氧化酶的保护作用，范围从有机化合物到天然化合物，如多酚类营养保健品。在这篇综述中，我们总结并讨论了抗氧化剂补充的优缺点，重点关注多酚、Q-Ter（辅酶Q10的可溶形式）、维生素E和N-乙酰半胱氨酸，它们在不同的噪声性听力损失动物模型中显示出巨大的耳保护作用，并且已在临床试验中被提出。
