聚羟基脂肪酸酯的生物医学应用
Biomedical Applications of Polyhydroxyalkanoates.
作者信息
Ray Subhasree, Kalia Vipin Chandra
机构信息
Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.
Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001 India.
出版信息
Indian J Microbiol. 2017 Sep;57(3):261-269. doi: 10.1007/s12088-017-0651-7. Epub 2017 Apr 22.
Abstract
Polyhydroxyalkanoates (PHA) are produced by a large number of microbes under stress conditions such as high carbon (C) availability and limitations of nutrients such as nitrogen, potassium, phosphorus, magnesium, and oxygen. Here, microbes store C as granules of PHAs-energy reservoir. PHAs have properties, which are quite similar to those of synthetic plastics. The unique properties, which make them desirable materials for biomedical applications is their biodegradability, biocompatibility, and non-toxicity. PHAs have been found suitable for various medical applications: biocontrol agents, drug carriers, biodegradable implants, tissue engineering, memory enhancers, and anticancer agents.
摘要
聚羟基脂肪酸酯（PHA）由大量微生物在应激条件下产生，如高碳（C）可用性以及氮、钾、磷、镁和氧等营养物质的限制。在此，微生物将碳储存为PHA颗粒——能量储存库。PHA具有与合成塑料非常相似的特性。使其成为生物医学应用理想材料的独特特性是其生物可降解性、生物相容性和无毒性。已发现PHA适用于各种医学应用：生物防治剂、药物载体、可生物降解植入物、组织工程、记忆增强剂和抗癌剂。
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