• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Biomedical Applications of Polyhydroxyalkanoates.聚羟基脂肪酸酯的生物医学应用
Indian J Microbiol. 2017 Sep;57(3):261-269. doi: 10.1007/s12088-017-0651-7. Epub 2017 Apr 22.
2
Exploiting Polyhydroxyalkanoates for Biomedical Applications.利用聚羟基脂肪酸酯用于生物医学应用。
Polymers (Basel). 2023 Apr 19;15(8):1937. doi: 10.3390/polym15081937.
3
The General Composition of Polyhydroxyalkanoates and Factors that Influence their Production and Biosynthesis.聚羟基烷酸酯的一般组成及影响其生产和生物合成的因素。
Curr Pharm Des. 2023;29(39):3089-3102. doi: 10.2174/0113816128263175231102061920.
4
Bacterial production of the biodegradable plastics polyhydroxyalkanoates.细菌生产可生物降解塑料聚羟基脂肪酸酯。
Int J Biol Macromol. 2014 Sep;70:208-13. doi: 10.1016/j.ijbiomac.2014.06.001. Epub 2014 Jun 26.
5
Sustainable applications of polyhydroxyalkanoates in various fields: A critical review.聚羟基烷酸酯在各个领域的可持续应用： 批判性回顾。
Int J Biol Macromol. 2022 Nov 30;221:1184-1201. doi: 10.1016/j.ijbiomac.2022.09.098. Epub 2022 Sep 14.
6
Biomedical applications of microbially engineered polyhydroxyalkanoates: an insight into recent advances, bottlenecks, and solutions.微生物工程聚羟基烷酸酯在生物医学中的应用：对最新进展、瓶颈和解决方案的深入了解。
Appl Microbiol Biotechnol. 2019 Mar;103(5):2007-2032. doi: 10.1007/s00253-018-09604-y. Epub 2019 Jan 15.
7
Binary polyhydroxyalkanoate systems for soft tissue engineering.用于软组织工程的二元聚羟基烷酸酯体系。
Acta Biomater. 2018 Apr 15;71:225-234. doi: 10.1016/j.actbio.2018.02.027. Epub 2018 Mar 2.
8
Biomedical Applications of Polyhydroxyalkanoate in Tissue Engineering.聚羟基脂肪酸酯在组织工程中的生物医学应用
Polymers (Basel). 2022 May 24;14(11):2141. doi: 10.3390/polym14112141.
9
Recent progress in the utilization of biosynthesized polyhydroxyalkanoates for biomedical applications - Review.生物合成聚羟基烷酸酯在生物医学应用中的利用进展综述。
Int J Biol Macromol. 2018 Dec;120(Pt A):1294-1305. doi: 10.1016/j.ijbiomac.2018.09.002. Epub 2018 Sep 4.
10
Polyhydroxyalkanoates: Next generation natural biomolecules and a solution for the world's future economy.聚羟基脂肪酸酯：下一代天然生物分子，也是解决世界未来经济的方案。
Int J Biol Macromol. 2021 Jan 1;166:297-321. doi: 10.1016/j.ijbiomac.2020.10.187. Epub 2020 Oct 27.

引用本文的文献

1
Fabrication and Evaluation of Polyhydroxyalkanoate-Based Nanoparticles for Curcumin Delivery in Biomedical Applications.用于生物医学应用中姜黄素递送的聚羟基脂肪酸酯基纳米颗粒的制备与评价
Molecules. 2025 Mar 8;30(6):1216. doi: 10.3390/molecules30061216.
2
Enhancing the Potential of PHAs in Tissue Engineering Applications: A Review of Chemical Modification Methods.提高聚羟基脂肪酸酯在组织工程应用中的潜力：化学改性方法综述
Materials (Basel). 2024 Nov 27;17(23):5829. doi: 10.3390/ma17235829.
3
Materials designed to degrade: structure, properties, processing, and performance relationships in polyhydroxyalkanoate biopolymers.用于降解的材料：聚羟基脂肪酸酯生物聚合物的结构、性能、加工及性能关系
Polym Chem. 2024 Oct 15;16(3):235-265. doi: 10.1039/d4py00623b. eCollection 2025 Jan 14.
4
Targeted PHA Microsphere-Loaded Triple-Drug System with Sustained Drug Release for Synergistic Chemotherapy and Gene Therapy.用于协同化疗和基因治疗的靶向负载PHA微球的三联药物系统，具有持续药物释放功能。
Nanomaterials (Basel). 2024 Oct 16;14(20):1657. doi: 10.3390/nano14201657.
5
Green Synthesis of Bioplastics from Microalgae: A State-of-the-Art Review.微藻生物塑料的绿色合成：最新综述
Polymers (Basel). 2024 May 8;16(10):1322. doi: 10.3390/polym16101322.
6
Manipulating Microbial Cell Morphology for the Sustainable Production of Biopolymers.操纵微生物细胞形态以实现生物聚合物的可持续生产
Polymers (Basel). 2024 Feb 1;16(3):410. doi: 10.3390/polym16030410.
7
Exploring polyhydroxyalkanoates biosynthesis using hydrocarbons as carbon source: a comprehensive review.利用碳氢化合物作为碳源探索聚羟基脂肪酸酯的生物合成：综述
Biodegradation. 2024 Aug;35(5):519-538. doi: 10.1007/s10532-023-10068-9. Epub 2024 Feb 4.
8
Phenotypic and genotypic characterization of sp. nov. and sp. nov., isolated from marine sediment, and genomic properties of the genus .海洋沉积物中分离的 sp. nov. 和 sp. nov. 的表型和基因型特征及 属的基因组特性。
Microb Genom. 2024 Jan;10(1). doi: 10.1099/mgen.0.001182.
9
Exploring Schwann Cell Behavior on Electrospun Polyhydroxybutyrate Scaffolds with Varied Pore Sizes and Fiber Thicknesses: Implications for Neural Tissue Engineering.探索雪旺细胞在具有不同孔径和纤维厚度的电纺聚羟基丁酸酯支架上的行为：对神经组织工程的意义。
Polymers (Basel). 2023 Dec 6;15(24):4625. doi: 10.3390/polym15244625.
10
Development of Polyhydroxybutyrate-Based Packaging Films and Methods to Their Ultrasonic Welding.基于聚羟基丁酸酯的包装薄膜的开发及其超声焊接方法。
Materials (Basel). 2023 Oct 10;16(20):6617. doi: 10.3390/ma16206617.

本文引用的文献

1
Influence of Hydroxyl Groups on the Cell Viability of Polyhydroxyalkanoate (PHA) Scaffolds for Tissue Engineering.羟基对用于组织工程的聚羟基脂肪酸酯（PHA）支架细胞活力的影响。
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3064-3075. doi: 10.1021/acsbiomaterials.6b00279. Epub 2016 Sep 1.
2
Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications.自组装蛋白质包被的聚羟基脂肪酸酯珠粒：性质与生物医学应用
ACS Biomater Sci Eng. 2017 Dec 11;3(12):3043-3057. doi: 10.1021/acsbiomaterials.6b00355. Epub 2016 Sep 13.
3
Influence of Cross-Linking on the Physical Properties and Cytotoxicity of Polyhydroxyalkanoate (PHA) Scaffolds for Tissue Engineering.交联对用于组织工程的聚羟基脂肪酸酯（PHA）支架物理性能和细胞毒性的影响。
ACS Biomater Sci Eng. 2015 Jul 13;1(7):567-576. doi: 10.1021/acsbiomaterials.5b00052. Epub 2015 Jun 8.
4
Effect of antibiotics on bacterial populations: a multi-hierachical selection process.抗生素对细菌群体的影响：一个多层次的选择过程。
F1000Res. 2017 Jan 17;6:51. doi: 10.12688/f1000research.9685.1. eCollection 2017.
5
Microbial Cometabolism and Polyhydroxyalkanoate Co-polymers.微生物共代谢与聚羟基脂肪酸酯共聚物
Indian J Microbiol. 2017 Mar;57(1):39-47. doi: 10.1007/s12088-016-0622-4. Epub 2016 Sep 28.
6
Genomic predictions can accelerate selection for resistance against Piscirickettsia salmonis in Atlantic salmon (Salmo salar).基因组预测可以加速大西洋鲑（Salmo salar）对鲑鱼立克次氏体抗性的选育。
BMC Genomics. 2017 Jan 31;18(1):121. doi: 10.1186/s12864-017-3487-y.
7
Co-metabolism of substrates by Bacillus thuringiensis regulates polyhydroxyalkanoate co-polymer composition.苏云金芽孢杆菌通过共代谢调控聚羟基烷酸共聚酯的组成。
Bioresour Technol. 2017 Jan;224:743-747. doi: 10.1016/j.biortech.2016.11.089. Epub 2016 Nov 23.
8
Reactive blends based on polyhydroxyalkanoates: Preparation and biomedical application.基于聚羟基脂肪酸酯的反应性共混物：制备及生物医学应用。
Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 2):1107-1119. doi: 10.1016/j.msec.2016.03.114. Epub 2016 Apr 7.
9
Experimental wound dressings of degradable PHA for skin defect repair.用于皮肤缺损修复的可降解聚羟基脂肪酸酯实验性伤口敷料。
J Mater Sci Mater Med. 2016 Nov;27(11):165. doi: 10.1007/s10856-016-5776-4. Epub 2016 Sep 21.
10
Biorefinery for Glycerol Rich Biodiesel Industry Waste.面向富含甘油的生物柴油工业废料的生物精炼厂。
Indian J Microbiol. 2016 Jun;56(2):113-25. doi: 10.1007/s12088-016-0583-7. Epub 2016 Apr 20.

聚羟基脂肪酸酯的生物医学应用

Biomedical Applications of Polyhydroxyalkanoates.

作者信息

Ray Subhasree, Kalia Vipin Chandra

机构信息

Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.

Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001 India.

出版信息

Indian J Microbiol. 2017 Sep;57(3):261-269. doi: 10.1007/s12088-017-0651-7. Epub 2017 Apr 22.

DOI:10.1007/s12088-017-0651-7
PMID:28904409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5574769/
Abstract

Polyhydroxyalkanoates (PHA) are produced by a large number of microbes under stress conditions such as high carbon (C) availability and limitations of nutrients such as nitrogen, potassium, phosphorus, magnesium, and oxygen. Here, microbes store C as granules of PHAs-energy reservoir. PHAs have properties, which are quite similar to those of synthetic plastics. The unique properties, which make them desirable materials for biomedical applications is their biodegradability, biocompatibility, and non-toxicity. PHAs have been found suitable for various medical applications: biocontrol agents, drug carriers, biodegradable implants, tissue engineering, memory enhancers, and anticancer agents.

摘要

聚羟基脂肪酸酯（PHA）由大量微生物在应激条件下产生，如高碳（C）可用性以及氮、钾、磷、镁和氧等营养物质的限制。在此，微生物将碳储存为PHA颗粒——能量储存库。PHA具有与合成塑料非常相似的特性。使其成为生物医学应用理想材料的独特特性是其生物可降解性、生物相容性和无毒性。已发现PHA适用于各种医学应用：生物防治剂、药物载体、可生物降解植入物、组织工程、记忆增强剂和抗癌剂。