Carter A T, Norton J D, Gibson Y, Avery R J
J Mol Biol. 1986 Mar 5;188(1):105-8. doi: 10.1016/0022-2836(86)90485-7.
A transcriptionally active sub-set of the dispersed mouse VL30 family of proviral genetic elements was shown to be highly transmissible as a murine leukaemia virus pseudotype. Newly acquired VL30 proviruses (present at 1 to 2 copies per cell) were shown to be transcriptionally active. These data substantiate the hypothesis that this process of duplicative transposition may have played a major role in the evolution of the gene family and also demonstrate that VL30 elements would be capable of mediating oncogene activation by a promoter-insertion-type mechanism during leukaemia virus-induced tumourgenesis.
已证明，分散的小鼠前病毒遗传元件VL30家族的一个转录活性亚组作为鼠白血病病毒假型具有高度传染性。新获得的VL30前病毒（每个细胞中有1至2个拷贝）具有转录活性。这些数据证实了以下假设：这种重复转座过程可能在该基因家族的进化中发挥了主要作用，并且还表明VL30元件在白血病病毒诱导的肿瘤发生过程中能够通过启动子插入型机制介导癌基因激活。
