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通过病毒假型转移至大鼠细胞的单个小鼠VL30元件保留了它们对蛋白激酶C激活剂的反应性。

Individual mouse VL30 elements transferred to rat cells by viral pseudotypes retain their responsiveness to activators of protein kinase C.

作者信息

Rodland K D, Brown A M, Magun B E

出版信息

Mol Cell Biol. 1987 Jun;7(6):2296-8. doi: 10.1128/mcb.7.6.2296-2298.1987.

DOI:10.1128/mcb.7.6.2296-2298.1987
PMID:3600664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365355/
Abstract

By exploiting the retroviral characteristics of mouse VL30 elements, we transferred individual copies of VL30 to Rat-1 cells by infection. Analysis of clonal isolates containing single VL30 elements integrated into the Rat-1 genome indicates that responsiveness to activators of protein kinase C is an inherent property of at least some of the VL30 sequences.

摘要

通过利用小鼠VL30元件的逆转录病毒特性，我们通过感染将单个VL30拷贝转移到Rat-1细胞中。对含有整合到Rat-1基因组中的单个VL30元件的克隆分离株的分析表明，对蛋白激酶C激活剂的反应性是至少一些VL30序列的固有特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/6bfdb894ebb8/molcellb00078-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/233bc61c2cfa/molcellb00078-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/f5cef7e49c65/molcellb00078-0269-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/6bfdb894ebb8/molcellb00078-0270-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/233bc61c2cfa/molcellb00078-0269-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/f5cef7e49c65/molcellb00078-0269-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae8a/365355/6bfdb894ebb8/molcellb00078-0270-a.jpg

相似文献

1
Individual mouse VL30 elements transferred to rat cells by viral pseudotypes retain their responsiveness to activators of protein kinase C.通过病毒假型转移至大鼠细胞的单个小鼠VL30元件保留了它们对蛋白激酶C激活剂的反应性。
Mol Cell Biol. 1987 Jun;7(6):2296-8. doi: 10.1128/mcb.7.6.2296-2298.1987.
2
Modulation of RNA expression by intracellular calcium. Existence of a threshold calcium concentration for induction of VL30 RNA by epidermal growth factor, endothelin, and protein kinase C.细胞内钙对RNA表达的调节。表皮生长因子、内皮素和蛋白激酶C诱导VL30 RNA存在钙浓度阈值。
J Biol Chem. 1990 Jul 5;265(19):11000-7.
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A novel approach to cloning transcriptionally active retrovirus-like genetic elements from mouse cells.一种从小鼠细胞中克隆具有转录活性的逆转录病毒样遗传元件的新方法。
Nucleic Acids Res. 1983 Sep 24;11(18):6243-54. doi: 10.1093/nar/11.18.6243.
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Expression and transmission of a rodent retrovirus-like (VL30) gene family.一种啮齿动物逆转录病毒样（VL30）基因家族的表达与传递。
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Efficient packaging of a specific VL30 retroelement by psi 2 cells which produce MoMLV recombinant retroviruses.产生莫洛尼鼠白血病病毒（MoMLV）重组逆转录病毒的psi 2细胞对特定VL30逆转录元件的有效包装。
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Regulation of VL30 gene expression by activators of protein kinase C.蛋白激酶C激活剂对VL30基因表达的调控
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Evidence for an early evolutionary origin and locus polymorphism of mouse VL30 DNA sequences.小鼠VL30 DNA序列的早期进化起源和基因座多态性的证据。
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Diverse long terminal repeats are associated with murine retroviruslike (VL30) elements.多样的长末端重复序列与鼠类逆转录病毒样（VL30）元件相关。
Mol Cell Biol. 1986 Apr;6(4):1276-82. doi: 10.1128/mcb.6.4.1276-1282.1986.
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Conservation patterns of mouse "virus-like" (VL30) DNA sequences.小鼠“病毒样”（VL30）DNA序列的保守模式。
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J Virol. 1995 Oct;69(10):6400-7. doi: 10.1128/JVI.69.10.6400-6407.1995.

引用本文的文献

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Independent transcriptional regulation of a single VL30 element by epidermal growth factor and activators of protein kinase C.表皮生长因子和蛋白激酶C激活剂对单个VL30元件的独立转录调控。
Mol Cell Biol. 1988 May;8(5):2247-50. doi: 10.1128/mcb.8.5.2247-2250.1988.
2
Harvey sarcoma virus genome contains no extensive sequences unrelated to those of other retroviruses except ras.哈维肉瘤病毒基因组除了癌基因ras外，不包含与其他逆转录病毒无关的大量序列。
J Virol. 1988 Sep;62(9):3540-3. doi: 10.1128/JVI.62.9.3540-3543.1988.
3
A single point mutation in the envelope gene is responsible for replication and XC fusion deficiency of the endogenous ecotropic C3H/He murine leukemia virus and for its repair in culture.

本文引用的文献

1
Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
Eur J Biochem. 1980 Jun;107(2):303-14. doi: 10.1111/j.1432-1033.1980.tb06030.x.
2
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus.逆转录病毒包装突变体的构建及其用于产生无辅助病毒的缺陷型逆转录病毒。
Cell. 1983 May;33(1):153-9. doi: 10.1016/0092-8674(83)90344-6.
3
Structure and expression of mouse VL30 genes.小鼠VL30基因的结构与表达
包膜基因中的单个点突变导致内源性亲嗜性C3H/He小鼠白血病病毒的复制和XC融合缺陷及其在培养中的修复。
J Virol. 1988 Mar;62(3):932-43. doi: 10.1128/JVI.62.3.932-943.1988.
4
Distinct helper virus requirements for Abelson murine leukemia virus-induced pre-B- and T-cell lymphomas.阿贝尔逊鼠白血病病毒诱导前B细胞和T细胞淋巴瘤对不同辅助病毒的需求
J Virol. 1989 May;63(5):2088-98. doi: 10.1128/JVI.63.5.2088-2098.1989.
5
NICER elements: a family of nerve growth factor-inducible cAMP-extinguishable retrovirus-like elements.NICER元件：一类神经生长因子诱导的可抑制环磷酸腺苷的逆转录病毒样元件。
Proc Natl Acad Sci U S A. 1990 May;87(10):3778-82. doi: 10.1073/pnas.87.10.3778.
6
Specificity of retroviral RNA packaging.逆转录病毒RNA包装的特异性
J Virol. 1991 Jan;65(1):71-80. doi: 10.1128/JVI.65.1.71-80.1991.
7
Identification of a novel enhancer element mediating calcium-dependent induction of gene expression in response to either epidermal growth factor or activation of protein kinase C.鉴定一种新型增强子元件，其介导在表皮生长因子或蛋白激酶C激活后基因表达的钙依赖性诱导。
Mol Cell Biol. 1992 Jun;12(6):2793-803. doi: 10.1128/mcb.12.6.2793-2803.1992.
Mol Cell Biol. 1983 Dec;3(12):2221-31. doi: 10.1128/mcb.3.12.2221-2231.1983.
4
Polyadenylylated RNA complementary to a mouse retrovirus-like multigene family is rapidly and specifically induced by epidermal growth factor stimulation of quiescent cells.与小鼠逆转录病毒样多基因家族互补的聚腺苷酸化RNA在静止细胞受到表皮生长因子刺激后被快速且特异性地诱导产生。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7317-21. doi: 10.1073/pnas.79.23.7317.
5
Patterns of genomic distribution and sequence heterogeneity of a murine "retrovirus-like" multigene family.小鼠“逆转录病毒样”多基因家族的基因组分布模式和序列异质性
J Virol. 1982 Jul;43(1):50-8. doi: 10.1128/JVI.43.1.50-58.1982.
6
Organization and expression of endogenous virus-like (VL30) DNA sequences in nontransformed and chemically transformed mouse embryo cells in culture.培养的未转化和化学转化小鼠胚胎细胞中内源性病毒样（VL30）DNA序列的组织与表达
Cancer Res. 1982 Feb;42(2):569-76.
7
Regulation of VL30 gene expression by activators of protein kinase C.蛋白激酶C激活剂对VL30基因表达的调控
J Biol Chem. 1986 Apr 15;261(11):5029-33.
8
Expression of retroviral sequences and oncogenes in murine hepatocellular tumors.逆转录病毒序列和癌基因在小鼠肝细胞瘤中的表达。
Cancer Res. 1986 Apr;46(4 Pt 2):1915-9.
9
Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.大鼠和小鼠细胞中存在缺陷的类逆转录病毒30S RNA种类，若被C型辅助病毒包装则具有感染性。
J Virol. 1979 Mar;29(3):964-72. doi: 10.1128/JVI.29.3.964-972.1979.
10
Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus.狒狒C型病毒从小鼠细胞中拯救内源性30S逆转录病毒序列。
J Virol. 1978 May;26(2):257-64. doi: 10.1128/JVI.26.2.257-264.1978.