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新型碳基复合材料的改性研究进展:合成、性能及生物技术/生物医学应用。

Recent advances in modification of novel carbon-based composites: Synthesis, properties, and biotechnological/ biomedical applications.

机构信息

Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi, 441-8580, Japan; Center for Nanotechnology (CNT), School of Engineering and Applied Sciences, Nile University, Sheikh Zayed, Giza, 16453, Egypt.

Nanotechnology Platforms, Discipline of Clinical Anatomy, School of Laboratory Medicine & Medical Sciences, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.

出版信息

Chem Biol Interact. 2023 Jul 1;379:110517. doi: 10.1016/j.cbi.2023.110517. Epub 2023 May 4.

Abstract

Nowadays, carbon-based materials owing to great interest in biomedical science/biotechnology and applied for effective diagnosis and treatment of disease. To enhance the effectiveness of carbon nanotubes (CNTs)/graphene-based materials for bio-medical science/technology applications, different kinds of surface modification/functionalization were developed for the attachment of metal oxides nanostructures, biomolecules and polymers. The attachment of pharmaceutical agents with CNTs/graphene, make it a favorable candidate in research field of bio-medical science/technology applications. Surface modified/functionalized CNTs and graphene derivatives materials integrated with pharmaceutical agents has been developed for the purpose of cancer therapy, antibacterial action, pathogens bio detection, drug and gene delivery. Surface modification or functionalization of CNT/graphene materials provides good platform for pharmaceutical agents attachment with improved surface Raman scattering, fluorescence and its quenching capability. Graphene-based biosensing and bioimaging technologies are widely applied to identify numerous trace level analytes. These fluorescent and electrochemical sensors are utilized primarily for detecting organic, inorganic, and biomolecules. In this article, we highlights and summarized overview of the current research progress concerned on the CNTs/graphene-based materials as a new generation materials for detection and treatment of diseases.

摘要

如今,碳基材料由于在生物医学科学/生物技术方面的巨大兴趣,被应用于疾病的有效诊断和治疗。为了提高碳纳米管(CNT)/石墨烯基材料在生物医学科学/技术应用中的有效性,开发了各种表面改性/功能化方法,用于附着金属氧化物纳米结构、生物分子和聚合物。将药物与 CNTs/石墨烯结合,使其成为生物医学科学/技术应用研究领域的理想候选材料。为了癌症治疗、抗菌作用、病原体生物检测、药物和基因传递的目的,已经开发了与药物结合的表面改性/功能化 CNT 和石墨烯衍生物材料。CNT/石墨烯材料的表面改性或功能化提供了一个良好的平台,用于药物附着,从而提高了表面拉曼散射、荧光及其猝灭能力。基于石墨烯的生物传感和生物成像技术广泛应用于识别众多痕量分析物。这些荧光和电化学传感器主要用于检测有机、无机和生物分子。本文重点总结了当前关于 CNTs/石墨烯基材料作为新一代疾病检测和治疗材料的研究进展。

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