Orndahl G, Selldén U, Hallin S, Wetterqvist H, Rindby A, Selin E
Acta Med Scand. 1986;219(4):407-14. doi: 10.1111/j.0954-6820.1986.tb03331.x.
We have previously reported the successful treatment of a patient with myotonic dystrophy with selenium and vitamin E. This paper deals with the treatment of a further five patients with myotonic dystrophy in different stages. All five patients improved subjectively and objectively in two or more respects. All improved their grip strength according to vigorimeter measurements (Martin), two normalized their gait, another two can now sit down on their heels and stand up, one patient can now walk on his toes, one can now get up from lying on the floor without using a chair and two patients have improved their physical capacity. Patients in early stages of the disease improved faster and more markedly than those in late stages. Electromyographical measurements also showed improvements, in that the myotonic discharges had diminished. The daily dose was 4 mg of Na2SeO3 and 600 mg of vitamin E. Serum concentration of selenium increased in all patients at the beginning of the treatment, but stabilized at a level slightly above the normal. No side-effects were observed.
我们之前曾报道过用硒和维生素E成功治疗一名强直性肌营养不良患者。本文论述了另外五名处于不同阶段的强直性肌营养不良患者的治疗情况。所有五名患者在两个或更多方面主观和客观上都有改善。根据握力计测量（马丁法），所有人的握力都有所增强，两名患者的步态恢复正常，另外两名患者现在能够足跟落地坐下并站起，一名患者现在能用脚尖行走，一名患者现在无需借助椅子就能从躺在地上起身，还有两名患者的身体能力有所提高。疾病早期的患者比晚期患者改善得更快、更明显。肌电图测量也显示有改善，强直放电减少。每日剂量为4毫克亚硒酸钠和600毫克维生素E。治疗开始时所有患者的血清硒浓度都升高了，但稳定在略高于正常的水平。未观察到副作用。
