间充质干细胞衍生的外泌体在缺血性脑卒中后炎症反应中的研究进展。
Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke.
机构信息
1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China.
2. Jiangsu Provincial Key Laboratory of Geriatric Disease Prevention and Control, Yangzhou 225001, Jiangsu Province, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022 Aug 5;51(4):500-506. doi: 10.3724/zdxbyxb-2022-0077.
Ischemic stroke is characterized by cute onset and high mortality. The suppression of neuroinflammation is crucial in the treatment of ischemic stroke. Exosomes derived from mesenchymal stem cell (MSC) have attracted extensive research attention due to their wide origin, small size, and containing large number of active components. Recent studies have shown that MSC-derived exosomes can inhibit the proinflammatory activity of microglia and astrocytes and stimulate their neuroprotective activity; also can inhibit neuroinflammation by regulating immune cells and inflammatory mediators. This article reviews the roles and related mechanism of MSC-derived exosomes in neuroinflammation after ischemic stroke, hoping to provide ideas and references for the development of a novel approach for the treatment of ischemic stroke diseases.
缺血性脑卒中的特点是发病急、死亡率高。抑制神经炎症在缺血性脑卒中的治疗中至关重要。间充质干细胞（MSC）来源的外泌体因其来源广泛、体积小、含有大量活性成分而受到广泛关注。最近的研究表明，MSC 来源的外泌体可以抑制小胶质细胞和星形胶质细胞的促炎活性，刺激其神经保护活性；还可以通过调节免疫细胞和炎症介质来抑制神经炎症。本文综述了 MSC 来源的外泌体在缺血性脑卒中后神经炎症中的作用及相关机制，以期为缺血性脑卒中疾病的治疗提供新的思路和参考。
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