Global Epidemiology, Office of the Chief Medical Officer, Janssen Research and Development, LLC, Titusville, NJ, USA.
Int J Colorectal Dis. 2023 May 19;38(1):135. doi: 10.1007/s00384-023-04417-6.
To estimate and compare annual prevalence and incidence, and demographic characteristics of patients with ulcerative colitis (UC) in Japan and the United States (US).
All patients with UC were identified from large employment-based healthcare claims databases (Japan Medical Data Center [JMDC] in Japan and IBM MarketScan Commercial Claims and Encounters database [CCAE] in the US), from 2010 to 2019. Cases were confirmed using International Classification of Disease-9/10 codes with/without Anatomical Therapeutic Chemical codes. Annual age-standardized prevalence and incidence rates were estimated for the JMDC by direct standardization using the CCAE as the standard population.
Patients with UC were younger in Japan than in the US and men were affected more than women, whereas the reverse was true in the US. Annual prevalence per 100,000 population increased significantly from 5 in 2010 to 98 in 2019 in Japan and from 158 to 233 in the US. Prevalence increased in men more than in women and in all age groups in Japan, whereas increases were observed similarly in men and women, and in the 6 to < 65-year age groups in the US. Annual incidence per 100,000 person-years increased significantly over time in both sexes and in all age groups in Japan, with higher increases in women and in ≥ 18 year-olds. UC incidence rates did not change over time in the US.
Ten-year trends in epidemiology of UC differ between Japan and the US. The data point to a growing disease burden in both countries that warrants investigation of measures for prevention and treatment.
估算并比较日本和美国溃疡性结肠炎（UC）患者的年患病率和发病率，以及人口统计学特征。
从大型就业型医疗保健索赔数据库（日本医疗数据中心[JMDC]和美国 IBM MarketScan 商业索赔和遭遇数据库[CCAE]）中确定所有 UC 患者。使用国际疾病分类第 9 版/第 10 版（ICD-9/10）代码和/或解剖治疗化学分类代码来确认病例。通过使用 CCAE 作为标准人群对 JMDC 进行直接标准化，估算了 2010 年至 2019 年期间的年龄标准化年患病率和发病率。
与美国相比，日本的 UC 患者更年轻，男性多于女性，而美国则相反。日本每 10 万人的年患病率从 2010 年的 5 人增加到 2019 年的 98 人，美国从 158 人增加到 233 人。日本男性和所有年龄组的患病率均显著增加，而女性和 6 岁至<65 岁年龄组的患病率也有所增加。日本两性和所有年龄组的年发病率均呈显著上升趋势，女性和≥18 岁人群的增长率更高。美国 UC 的发病率在这十年间没有变化。
日本和美国 UC 的十年流行病学趋势存在差异。这些数据表明，两国的疾病负担都在增加，需要调查预防和治疗措施。
