Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
BMC Pediatr. 2023 May 22;23(1):254. doi: 10.1186/s12887-023-04081-3.
Diarrhoea is the most commonly related disease caused by Aeromonas. To improve knowledge on prevalence, this systematic review and meta-analysis was performed to evaluate the global prevalence of Aeromonas in children with diarrhoea worldwide.
We systematically searched PubMed, Google scholar, Wiley Online Library, ScienceDirect, and Web of sciences to identify all cross-sectional published papers between 2000 and 10 July 2022. After initial scrutinizing, 31 papers reporting the prevalence of Aeromonas in children with diarrhoea were found to be adequate for meta-analysis. The statistical study was accompanied by using random effects models.
A total of 5660 identified papers, 31 cross-sectional studies encompassing 38,663 participants were included in the meta-analysis. The pooled prevalence of Aeromonas in children with diarrhoea worldwide was 4.2% (95% CI 3.1-5.6%). In the subgroup analysis, the highest prevalence was seen among children in Upper middle-income countries with pooled prevalence of 5.1% (95% CI 2.8-9.2%). The prevalence of Aeromonas in children with diarrhoea was higher in countries with populations of over 100 million people (9.4%; 95% CI 5.6-15.3%), and water and sanitation quality score of less than 25% (8.8%; 95% CI 5.2-14.4%). Additionally, Cumulative Forest Plot showed a decreasing trend in the prevalence of Aeromonas infection in children with diarrhoea over time (P = 0.0001).
The results of this study showed a better comprehension of Aeromonas prevalence in children with diarrhoea on a global scale. As well as our findings showed that much work is still required to decline the burden of bacterial diarrhoea in countries with high populations, low-level income, and unsanitary water.
腹泻是气单胞菌最常见的相关疾病。为了提高对其流行率的认识，本系统评价和荟萃分析旨在评估全球范围内腹泻儿童中气单胞菌的流行率。
我们系统地检索了 PubMed、Google Scholar、Wiley Online Library、ScienceDirect 和 Web of Sciences，以确定 2000 年至 2022 年 7 月 10 日期间发表的所有横断面研究论文。经过初步筛选，发现 31 篇报告腹泻儿童中气单胞菌流行率的论文适合进行荟萃分析。统计研究伴随着使用随机效应模型。
共检索到 5660 篇论文，其中 31 项横断面研究共纳入 38663 名参与者纳入荟萃分析。全球范围内腹泻儿童中气单胞菌的总流行率为 4.2%（95%CI 3.1-5.6%）。在亚组分析中，中高收入国家儿童的流行率最高，为 5.1%（95%CI 2.8-9.2%）。人口超过 1 亿的国家和水和环境卫生质量评分低于 25%的国家（5.6-15.3%）儿童中，腹泻儿童中气单胞菌的流行率更高（9.4%；95%CI 5.6-15.3%）。此外，累积森林图显示，随着时间的推移，腹泻儿童中气单胞菌感染的流行率呈下降趋势（P=0.0001）。
本研究结果更好地了解了全球范围内腹泻儿童中气单胞菌的流行率。我们的研究结果表明，在人口众多、收入水平低、环境卫生条件差的国家，仍需要做大量工作来降低细菌性腹泻的负担。
