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经策展和协调的人类膳食纤维干预研究中的肠道微生物 16S rRNA 扩增子数据。

Curated and harmonized gut microbiome 16S rRNA amplicon data from dietary fiber intervention studies in humans.

机构信息

Dept. of Ecology and Evolutionary Biology, University of California, Irvine, USA.

Rush Center for Integrated Microbiome and Chronobiology, Rush University Medical Center, Chicago, USA.

出版信息

Sci Data. 2023 Jun 2;10(1):346. doi: 10.1038/s41597-023-02254-4.

Abstract

Next generation amplicon sequencing has created a plethora of data from human microbiomes. The accessibility to this scientific data and its corresponding metadata is important for its reuse, to allow for new discoveries, verification of published results, and serving as path for reproducibility. Dietary fiber consumption has been associated with a variety of health benefits that are thought to be mediated by gut microbiota. To enable direct comparisons of the response of the gut microbiome to fiber, we obtained 16S rRNA sequencing data and its corresponding metadata from 11 fiber intervention studies for a total of 2,368 samples. We provide curated and pre-processed genetic data and common metadata for comparison across the different studies.

摘要

下一代扩增子测序技术从人类微生物组中产生了大量数据。获取这些科学数据及其相应的元数据对于其重复使用非常重要,这可以促进新发现、验证已发表的结果,并为可重复性提供途径。膳食纤维的摄入与多种健康益处有关,这些益处被认为是通过肠道微生物群介导的。为了能够直接比较膳食纤维对肠道微生物组的反应,我们从 11 项膳食纤维干预研究中获得了总计 2368 个样本的 16S rRNA 测序数据及其相应的元数据。我们提供经过策展和预处理的遗传数据以及常见元数据,以便在不同的研究中进行比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9c5/10238384/5cbb786b083f/41597_2023_2254_Fig1_HTML.jpg

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