非药物干预措施对 COVID-19 大流行期间土耳其循环呼吸病毒的影响。
Impact of non-pharmaceutical interventions on circulating respiratory viruses during the COVID-19 pandemic in Turkey.
机构信息
From the Department of Medical Microbiology, Ankara Bilkent City Hospital, Ankara, Turkey.
From the Department of Medical Microbiology, Alanya Alaaddin Keykubat University, Antalya Turkey.
出版信息
Ann Saudi Med. 2023 May-Jun;43(3):143-153. doi: 10.5144/0256-4947.2023.143. Epub 2023 Jun 1.
BACKGROUND
Non-pharmaceutical interventions (NPIs) applied to limit the SARS-CoV-2 pandemic also affect the circulation and seasonal characteristics of other respiratory viruses.
OBJECTIVES
Assess the impact of NPIs on the spread and seasonal characteristics of non-SARS-CoV-2 respiratory viruses and examine viral respiratory co-infections.
DESIGN
Retrospective cohort SETTING: Single center in Turkey.
PATIENTS AND METHODS
Syndromic multiplex viral polymerase chain reaction (mPCR) panel results of patients admitted to the Ankara Bilkent City Hospital with symptoms of acute respiratory tract infection between April 1, 2020 and October 30, 2022 were evaluated. Two study periods before and after 1 July 2021, when the restrictions were discontinued, were statistically analyzed and compared to determine the effect of NPIs on circulating respiratory viruses.
MAIN OUTCOME MEASURES
Prevalence of respiratory viruses as determined by syndromic mPCR panel.
SAMPLE SIZE
11300 patient samples were evaluated.
RESULTS
At least one respiratory tract virus was detected in 6250 (55.3%) patients. Of these, at least one respiratory virus was detected in 5% in the first period (between April 1, 2020 and June 30, 2021, when NPIs were applied), and in 95% in the second period (between July 1, 2021 and October 30, 2022, when NPIs were relaxed). After the removal of NPIs, there was a statistically significant increase in hRV/EV, RSV-A/B, Flu A/H3, hBoV, hMPV, PIV-1, PIV-4, hCoV-OC43, PIV-2 and hCoV-NL63 (<.05). In the 2020-2021 season, when strict NPIs were applied, all respiratory viruses evaluated did not have the usual seasonal peak and there were no seasonal influenza epidemics during this period.
CONCLUSIONS
NPIs resulted in a dramatic decrease in the prevalence of respiratory viruses and notable disruption of seasonal characteristics.
LIMITATIONS
Single-center study and retrospective.
CONFLICT OF INTEREST
None.
背景
非药物干预（NPIs）应用于限制 SARS-CoV-2 大流行也会影响其他呼吸道病毒的传播和季节性特征。
目的
评估 NPIs 对非 SARS-CoV-2 呼吸道病毒传播和季节性特征的影响，并检查病毒呼吸道合并感染。
设计
回顾性队列研究
设置
土耳其的一个单一中心。
患者和方法
评估 2020 年 4 月 1 日至 2022 年 10 月 30 日期间因急性呼吸道感染症状入住安卡拉比伦特市医院的患者的综合征性多重病毒聚合酶链反应（mPCR）面板结果。对 2021 年 7 月 1 日之前和之后的两个研究期（限制措施停止时）进行统计学分析和比较，以确定 NPIs 对循环呼吸道病毒的影响。
主要观察指标
综合征性 mPCR 面板确定的呼吸道病毒患病率。
样本量
评估了 11300 名患者的样本。
结果
至少有一种呼吸道病毒在 6250 名（55.3%）患者中被检测到。其中，第一个时期（2020 年 4 月 1 日至 2021 年 6 月 30 日，应用 NPIs 时）至少有 5%的患者至少有一种呼吸道病毒被检测到，第二个时期（2021 年 7 月 1 日至 2022 年 10 月 30 日，NPIs 放宽时）则为 95%。在取消 NPIs 后，hRV/EV、RSV-A/B、Flu A/H3、hBoV、hMPV、PIV-1、PIV-4、hCoV-OC43、PIV-2 和 hCoV-NL63 的检出率均有统计学显著增加（<0.05）。在 2020-2021 年严格应用 NPIs 的季节，评估的所有呼吸道病毒均未出现通常的季节性高峰，在此期间也未出现季节性流感流行。
结论
NPIs 导致呼吸道病毒的患病率显著下降，并显著破坏了季节性特征。
局限性
单中心研究和回顾性研究。
利益冲突
无。
Zotero 插件