Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Prenatal Diagnosis and High Risk Pregnancy Unit, Department of Woman, Child and of General and Specialized Surgery, University "Luigi Vanvitelli", Naples, Italy.
J Diabetes Res. 2021 Nov 25;2021:9994734. doi: 10.1155/2021/9994734. eCollection 2021.
Microbiota composition is progressively being connected to different physiologic effects, such as glucose metabolism, and also to different pathologies, such as gestational diabetes mellitus (GDM). GDM is a public health concern that affects an important percentage of pregnancies and is correlated with many adverse maternal and neonatal outcomes. An increasing number of studies are showing some connections between specific microbial composition of the gut microbiota and development of GDM and adverse outcomes in mothers and neonates. The aim of this review is to analyze the available data on microbial changes that characterize healthy pregnancies and pregnancies complicated by GDM and to understand the correlation of these changes with adverse maternal outcomes; this review will also discuss the consequences of these maternal gut microbiome alterations on neonatal microbiota composition and neonatal long-term outcomes.
肠道微生物组成逐渐与不同的生理效应相关联，例如葡萄糖代谢，也与不同的疾病相关联，例如妊娠期糖尿病（GDM）。GDM 是一个公共卫生关注点，影响着很大一部分妊娠，并与许多不良的母婴结局相关。越来越多的研究表明，肠道微生物群的特定微生物组成与 GDM 的发展以及母婴不良结局之间存在一定联系。本综述的目的是分析现有的关于健康妊娠和 GDM 妊娠中微生物变化的特征的数据，并了解这些变化与不良母婴结局的相关性；本综述还将讨论这些母体肠道微生物组改变对新生儿微生物组组成和新生儿长期结局的影响。
