老年患者眼轴长度与干眼关系中的性别差异。
Sex differences in the relationship between axial length and dry eye in elderly patients.
作者信息
Ayaki Masahiko, Torii Hidemasa, Yotsukura Erisa, Negishi Kazuno
机构信息
Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
Otake Eye Clinic, Kanagawa, Japan.
出版信息
Front Med (Lausanne). 2023 Jun 2;10:1170696. doi: 10.3389/fmed.2023.1170696. eCollection 2023.
PURPOSE
The aim of this study was to explore the association between myopia and dry eye (DE)-related ocular parameters.
METHODS
We recruited a total of 460 patients (mean age, 73.6 years; 40.2% men) and performed DE-related, axial length (AL) and retinal examinations. Statistical analysis revealed a significant sex difference in AL, strip meniscometry value, corneal staining score, corneal endothelial cell density, ganglion cell complex (GCC) thickness, and full macular thickness. AL was strongly age- and sex-dependent, so subsequent analyses were stratified by sex.
RESULTS
Among DE-related parameters, strip meniscometry value (ß = -0.167, = 0.033) and corneal endothelial cell density (ß = -0.139, = 0.023) were correlated with AL in women but not in men. Regarding retinal parameters, GCC thickness and full macular thickness were correlated with AL in women but not in men.
CONCLUSION
The current results suggest a relationship between tear production and AL in elderly women and support the hypothesis that there may be a common upstream factor including the parasympathetic nervous system in the association between tear production and AL or DE and myopia.
目的
本研究旨在探讨近视与干眼（DE）相关眼部参数之间的关联。
方法
我们共招募了460名患者（平均年龄73.6岁；男性占40.2%），并进行了与干眼相关、眼轴长度（AL）和视网膜检查。统计分析显示，在眼轴长度、带状睑裂测量值、角膜染色评分、角膜内皮细胞密度、神经节细胞复合体（GCC）厚度和黄斑全层厚度方面存在显著的性别差异。眼轴长度强烈依赖于年龄和性别，因此后续分析按性别进行分层。
结果
在与干眼相关的参数中，带状睑裂测量值（β = -0.167，P = 0.033）和角膜内皮细胞密度（β = -0.139，P = 0.023）在女性中与眼轴长度相关，而在男性中不相关。关于视网膜参数，神经节细胞复合体厚度和黄斑全层厚度在女性中与眼轴长度相关，而在男性中不相关。
结论
目前的结果表明老年女性泪液生成与眼轴长度之间存在关联，并支持以下假设：在泪液生成与眼轴长度或干眼与近视的关联中，可能存在包括副交感神经系统在内的共同上游因素。
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