Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhuo, 646000, China.
Oral & Maxillofacial Reconstruction and Regeneration of Luzhou Key Laboratory, Luzhou, 646000, China.
Biomed Eng Online. 2023 Jun 19;22(1):62. doi: 10.1186/s12938-023-01120-z.
Decellularized vascular matrix is a natural polymeric biomaterial that comes from arteries or veins which are removed the cellular contents by physical, chemical and enzymatic means, leaving only the cytoskeletal structure and extracellular matrix to achieve cell adhesion, proliferation and differentiation and creating a suitable microenvironment for their growth. In recent years, the decellularized vascular matrix has attracted much attention in the field of tissue repair and regenerative medicine due to its remarkable cytocompatibility, biodegradability and ability to induce tissue regeneration. Firstly, this review introduces its basic properties and preparation methods; then, it focuses on the application and research of composite scaffold materials based on decellularized vascular matrix in vascular tissue engineering in terms of current in vitro and in vivo studies, and briefly outlines its applications in other tissue engineering fields; finally, it looks into the advantages and drawbacks to be overcome in the application of decellularized vascular matrix materials. In conclusion, as a new bioactive material for building engineered tissue and repairing tissue defects, decellularized vascular matrix will be widely applied in prospect.
去细胞血管基质是一种天然的聚合物生物材料，来源于通过物理、化学和酶方法去除细胞内容物的动脉或静脉，只留下细胞骨架结构和细胞外基质，以实现细胞黏附、增殖和分化，并为其生长创造合适的微环境。近年来，由于其显著的细胞相容性、生物降解性和诱导组织再生的能力，去细胞血管基质在组织修复和再生医学领域引起了广泛关注。首先，本文介绍了其基本性质和制备方法；然后，重点介绍了基于去细胞血管基质的复合支架材料在血管组织工程中的应用和研究，根据目前的体外和体内研究情况进行了概述，并简要介绍了其在其他组织工程领域的应用；最后，探讨了去细胞血管基质材料应用中需要克服的优缺点。总之，作为构建工程组织和修复组织缺陷的新型生物活性材料，去细胞血管基质具有广阔的应用前景。
