Department of Dermatology, Oregon Health & Science University, Chicago, IL, US.
National Eczema Association, Oregon Health & Science University, Chicago, IL, USA.
Acta Derm Venereol. 2023 Jun 20;103:adv6520. doi: 10.2340/actadv.v103.6520.
Despite the need for improved eczema therapies and a rapid increase in available eczema clinical trials, participation remains low. The aim of this study was to identify factors associated with clinical trial awareness, interest, and barriers to enrolment and participation. An online survey, administered 1 May to 6 June 2020 to adults (≥ 18 years) with eczema in the USA, was analysed. Among 800 patients included, mean age was 49.4 years, most respondents were female (78.1%), White (75.4%), non-Hispanic (91.4%), and geographically living in an urban/suburban area (Rural-Urban Continuum Codes (RUCC) 1-3, 90.8%). Only 9.7% of respondents reported previous participation in clinical trials, while 57.1% had considered participation and 33.2% never considered participation. Higher satisfaction with current eczema therapy, clinical trial literacy, and confidence in finding eczema trial information were all associated with clinical trial awareness, interest, and successful participation. Younger age and having atopic dermatitis were associated with increased awareness, while female gender was a barrier to interest and successful participation.
尽管需要改进湿疹疗法，并且可用于湿疹临床试验的数量迅速增加，但参与率仍然很低。本研究旨在确定与临床试验意识、兴趣以及参与和参与障碍相关的因素。对 2020 年 5 月 1 日至 6 月 6 日期间美国患有湿疹的成年人（≥18 岁）进行了一项在线调查，并对其进行了分析。在纳入的 800 名患者中，平均年龄为 49.4 岁，大多数受访者为女性（78.1%）、白人（75.4%）、非西班牙裔（91.4%），并且居住在城市/郊区（农村-城市连续体代码（RUCC）1-3，90.8%）。只有 9.7%的受访者报告曾参与过临床试验，而 57.1%的受访者曾考虑过参与，33.2%的受访者从未考虑过参与。对当前湿疹治疗的满意度更高、临床试验素养更高、对寻找湿疹试验信息的信心更高，这些都与临床试验意识、兴趣和成功参与有关。年龄较小和患有特应性皮炎与意识提高有关，而女性则是兴趣和成功参与的障碍。
