Jiji Merin Grace, Ninan Merin Ann, Thomas V P, Thomas Binoy T
Phycotechnology laboratory, Post Graduate and Research Department of Botany, Catholicate college, Pathanamthitta, Kerala 689645 India.
Vegetos. 2023 Apr 27:1-6. doi: 10.1007/s42535-023-00636-y.
Infectious diseases are always a threat to all living beings. Today, in this world pathogens have no difficulty reaching anywhere. Every year new and deadly diseases are born and most of them are caused by viruses. Vaccines can provide lifelong immunity against infectious diseases, but the production cost of vaccines is unaffordable for a layman and traditional vaccines have certain limitations with storage and delivery. However, edible vaccines have shifted this paradigm and have received acceptance all over the world, especially in developing countries. Microalgae are one of the potential candidates for developing edible vaccines. Modifying microalgae as edible vaccines are gaining worldwide attention, especially in the world of science. Microalgae can augment the immune system as they are a promising source for antigen carriers and many of them are regarded as safe to eat. Moreover, they are a pantry of proteins, vitamins, minerals, and other secondary metabolites like alkaloids, phenols, and terpenes. In addition, being resistant to animal pathogens they are less sophisticated for genetic modification. This review analyses the potential scope of microalgae as an edible vaccine source.
传染病始终对所有生物构成威胁。如今，在这个世界上，病原体到达任何地方都没有困难。每年都会出现新的致命疾病，其中大多数是由病毒引起的。疫苗可以提供针对传染病的终身免疫力，但疫苗的生产成本对于外行来说难以承受，而且传统疫苗在储存和运输方面有一定局限性。然而，可食用疫苗改变了这一模式，并在全世界，尤其是在发展中国家得到了认可。微藻是开发可食用疫苗的潜在候选者之一。将微藻改造为可食用疫苗正受到全球关注，尤其是在科学界。微藻可以增强免疫系统，因为它们是抗原载体的一个有前途的来源，而且许多微藻被认为食用安全。此外，它们富含蛋白质、维生素、矿物质以及其他次生代谢产物，如生物碱、酚类和萜类。此外，由于它们对动物病原体具有抗性，因此进行基因改造相对简单。本综述分析了微藻作为可食用疫苗来源的潜在范围。
