Hutomo Dimas Ilham, Amir Lisa, Suniarti Dewi Fatma, Bachtiar Endang Winiati, Soeroso Yuniarti
Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta 10430, Indonesia.
Polymers (Basel). 2023 Jun 6;15(12):2591. doi: 10.3390/polym15122591.
Hydrogel is considered a promising scaffold biomaterial for gingival regeneration. In vitro experiments were carried out to test new potential biomaterials for future clinical practice. The systematic review of such in vitro studies could synthesize evidence of the characteristics of the developing biomaterials. This systematic review aimed to identify and synthesize in vitro studies that assessed the hydrogel scaffold for gingival regeneration.
Data on experimental studies on the physical and biological properties of hydrogel were synthesized. A systematic review of the PubMed, Embase, ScienceDirect, and Scopus databases was conducted according to the Preferred Reporting System for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement guidelines. In total, 12 original articles on the physical and biological properties of hydrogels for gingival regeneration, published in the last 10 years, were identified.
One study only performed physical property analyses, two studies only performed biological property analyses, and nine studies performed both physical and biological property analyses. The incorporation of various natural polymers such as collagen, chitosan, and hyaluronic acids improved the biomaterial characteristics. The use of synthetic polymers faced some drawbacks in their physical and biological properties. Peptides, such as growth factors and arginine-glycine-aspartic acid (RGD), can be used to enhance cell adhesion and migration. Based on the available primary studies, all studies successfully present the potential of hydrogel characteristics in vitro and highlight the essential biomaterial properties for future periodontal regenerative treatment.
水凝胶被认为是用于牙龈再生的一种有前景的支架生物材料。开展了体外实验以测试用于未来临床实践的新型潜在生物材料。对此类体外研究进行系统评价能够综合新兴生物材料特性的证据。本系统评价旨在识别并综合评估用于牙龈再生的水凝胶支架的体外研究。
综合了关于水凝胶物理和生物学特性的实验研究数据。根据系统评价与Meta分析的首选报告系统（PRISMA）2020声明指南，对PubMed、Embase、ScienceDirect和Scopus数据库进行了系统评价。共识别出过去10年发表的12篇关于用于牙龈再生的水凝胶物理和生物学特性的原创文章。
1项研究仅进行了物理特性分析，2项研究仅进行了生物学特性分析，9项研究同时进行了物理和生物学特性分析。加入各种天然聚合物，如胶原蛋白、壳聚糖和透明质酸，改善了生物材料的特性。合成聚合物的使用在其物理和生物学特性方面存在一些缺点。肽，如生长因子和精氨酸-甘氨酸-天冬氨酸（RGD），可用于增强细胞黏附和迁移。基于现有的初步研究，所有研究均成功展示了水凝胶特性在体外的潜力，并突出了未来牙周再生治疗所需的生物材料特性。
