Hausman Hanna K, Hardcastle Cheshire, Kraft Jessica N, Evangelista Nicole D, Boutzoukas Emanuel M, O'Shea Andrew, Albizu Alejandro, Langer Kailey, Van Etten Emily J, Bharadwaj Pradyumna K, Song Hyun, Smith Samantha G, Porges Eric, Hishaw Georg A, Wu Samuel, DeKosky Steven, Alexander Gene E, Marsiske Michael, Cohen Ronald, Woods Adam J
Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Neuroimage Rep. 2022 Jun;2(2). doi: 10.1016/j.ynirp.2022.100085. Epub 2022 Feb 25.
Minimizing head motion during functional magnetic resonance imaging (fMRI) is important for maintaining the integrity of neuroimaging data. While there are a variety of techniques to control for head motion, oftentimes, individuals with excessive in-scanner motion are removed from analyses. Movement in the scanner tends to increase with age; however, the cognitive profile of these "high-movers" in older adults has yet to be explored. This study aimed to assess the association between in-scanner head motion (i.e., number of "invalid scans" flagged as motion outliers) and cognitive functioning (e.g., executive functioning, processing speed, and verbal memory performance) in a sample of 282 healthy older adults. Spearman's Rank-Order correlations showed that a higher number of invalid scans was significantly associated with poorer performance on tasks of inhibition and cognitive flexibility and with older age. Since performance in these domains tend to decline as a part of the non-pathological aging process, these findings raise concerns regarding the potential systematic exclusion due to motion of older adults with lower executive functioning in neuroimaging samples. Future research should continue to explore prospective motion correction techniques to better ensure the collection of quality neuroimaging data without excluding informative participants from the sample.
在功能磁共振成像（fMRI）期间尽量减少头部运动对于维持神经成像数据的完整性很重要。虽然有多种控制头部运动的技术，但通常，扫描仪内运动过多的个体在分析时会被排除。扫描仪内的运动往往会随着年龄增长而增加；然而，老年人中这些“高运动者”的认知特征尚未得到探索。本研究旨在评估282名健康老年人样本中扫描仪内头部运动（即标记为运动异常值的“无效扫描”数量）与认知功能（如执行功能、处理速度和言语记忆表现）之间的关联。斯皮尔曼等级相关显示，无效扫描数量越多，与抑制和认知灵活性任务表现较差以及年龄较大显著相关。由于这些领域的表现作为非病理性衰老过程的一部分往往会下降，这些发现引发了对神经成像样本中执行功能较低的老年人因运动而可能被系统排除的担忧。未来的研究应继续探索前瞻性运动校正技术，以更好地确保收集高质量的神经成像数据，而不将有价值的参与者排除在样本之外。
