来自寄生于橄榄绿柄桑（Enantia chlorantha Oliv.）中的普鲁士菌（Preussia sp.）的抗疟和细胞毒性二苯并呋喃
Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv.
作者信息
Talontsi Ferdinand Mouafo, Lamshöft Marc, Douanla-Meli Clovis, Kouam Simeon Fogue, Spiteller Michael
机构信息
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Institute of Biology, University of Kassel, Heinrich-Plett-Strasse 40, D-34132 Kassel, Germany.
出版信息
Fitoterapia. 2014 Mar;93:233-8. doi: 10.1016/j.fitote.2014.01.003. Epub 2014 Jan 17.
Two unusual dibenzofurans, preussiafurans A-B (1-2), together with six known compounds have been isolated from the fungus Preussia sp. occurring in Enantia chlorantha Oliv. The structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis. Compounds 1-4 showed antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum (NF54) and moderate cytotoxicity on L6 cell lines with IC50 values of 8.67 and 14.8 μM, respectively.
从生长在滇南风吹楠（Enantia chlorantha Oliv.）上的普鲁士菌（Preussia sp.）中分离出了两种不寻常的二苯并呋喃，即普鲁士呋喃A - B（1 - 2），以及六种已知化合物。其结构通过一维和二维核磁共振光谱及质谱分析得以确定。化合物1 - 4对氯喹耐药恶性疟原虫（NF54）的红细胞阶段显示出抗疟活性，并且对L6细胞系具有中等细胞毒性，IC50值分别为8.67和14.8 μM。
Zotero 插件