School of Mechanical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
Shandong Institute of Mechanical Design and Research, Jinan, 250031, China.
Odontology. 2023 Oct;111(4):813-829. doi: 10.1007/s10266-023-00832-x. Epub 2023 Jul 5.
Titanium and its alloys are the preferred materials for medical implants. However, easy infection is a fatal shortcoming of Ti implants. Fortunately, the ongoing development of antibacterial implant materials is a promising solution, and Ti alloys with antibacterial properties hold immense potential for medical applications. In this review, we briefly outline the mechanisms of bacterial colonization and biofilm formation on implants; discuss and classify the major antimicrobials currently in use and development, including inorganic and organic antimicrobials; and describe the important role of antimicrobials in the development of implant materials for clinical applications. Strategies and challenges related to improving the antimicrobial properties of implant materials as well as the prospects of antibacterial Ti alloys in the medical field are also discussed.
钛及钛合金是医用植入物的首选材料。然而，钛植入物易感染是其致命的缺点。幸运的是，抗菌植入材料的不断发展为这一问题提供了有前景的解决方案，具有抗菌性能的钛合金在医学应用中具有巨大的潜力。在这篇综述中，我们简要概述了细菌在植入物上定植和生物膜形成的机制；讨论和分类了目前正在使用和开发的主要抗菌剂，包括无机和有机抗菌剂；并描述了抗菌剂在开发用于临床应用的植入物材料中的重要作用。还讨论了提高植入物材料抗菌性能的策略和挑战，以及抗菌钛合金在医学领域的前景。
