Chen Na, Wang Yan-Lin, Sun Hui-Fang, Wang Zhuo-Ya, Zhang Qi, Fan Fei-Yan, Ma Yu-Cheng, Liu Fei-Xiang, Zhang Yun-Ke
First School of Clinical Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China.
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
World J Stem Cells. 2023 Jun 26;15(6):561-575. doi: 10.4252/wjsc.v15.i6.561.
The high incidence and disability rates of stroke pose a heavy burden on society. Inflammation is a significant pathological reaction that occurs after an ischemic stroke. Currently, therapeutic methods, except for intravenous thrombolysis and vascular thrombectomy, have limited time windows. Mesenchymal stem cells (MSCs) can migrate, differentiate, and inhibit inflammatory immune responses. Exosomes (Exos), which are secretory vesicles, have the characteristics of the cells from which they are derived, making them attractive targets for research in recent years. MSC-derived exosomes can attenuate the inflammatory response caused by cerebral stroke by modulating damage-associated molecular patterns. In this review, research on the inflammatory response mechanisms associated with Exos therapy after an ischemic injury is discussed to provide a new approach to clinical treatment.
中风的高发病率和致残率给社会带来了沉重负担。炎症是缺血性中风后发生的一种重要病理反应。目前，除静脉溶栓和血管取栓外，治疗方法的时间窗有限。间充质干细胞（MSCs）可以迁移、分化并抑制炎症免疫反应。外泌体（Exos）作为分泌性囊泡，具有其来源细胞的特性，使其成为近年来有吸引力的研究靶点。间充质干细胞衍生的外泌体可以通过调节损伤相关分子模式来减轻脑卒中介导的炎症反应。在这篇综述中，我们讨论了与缺血性损伤后外泌体治疗相关的炎症反应机制的研究，以为临床治疗提供新的方法。
