用莱姆病螺旋体对仓鼠进行被动免疫以抵抗实验性感染。
Passive immunization of hamsters against experimental infection with the Lyme disease spirochete.
作者信息
Johnson R C, Kodner C, Russell M
出版信息
Infect Immun. 1986 Sep;53(3):713-4. doi: 10.1128/iai.53.3.713-714.1986.
Abstract
Hamsters passively immunized with as little as 0.0125 ml of immune rabbit serum (indirect fluorescent-antibody titer, 1:8,192) were protected from challenge with 1,000 50% infective doses of Borrelia burgdorferi. Cross-protection studies with Minnesota and Connecticut isolates of B. burgdorferi indicated no major differences in their capacity to elicit mutually protective antibodies in rabbits.
摘要
用低至0.0125毫升免疫兔血清（间接荧光抗体效价为1:8,192）进行被动免疫的仓鼠，可免受1000个50%感染剂量的伯氏疏螺旋体的攻击。对来自明尼苏达州和康涅狄格州的伯氏疏螺旋体分离株进行的交叉保护研究表明，它们在兔体内引发相互保护性抗体的能力没有重大差异。
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