环氧乙烷暴露。通过分析肺泡气和血液进行生物监测。
Ethylene oxide exposure. Biological monitoring by analysis of alveolar air and blood.
作者信息
Brugnone F, Perbellini L, Faccini G B, Pasini F, Bartolucci G B, DeRosa E
出版信息
Int Arch Occup Environ Health. 1986;58(2):105-12. doi: 10.1007/BF00380761.
Occupational exposure to ethylene oxide (ETO) was studied in ten workers employed in a hospital sterilizer unit by testing environmental air, alveolar air and blood during and at the end of the workshift. Alveolar (Ca) and blood (Cb) ETO concentrations were correlated with each other (r = 0.744, n = 36, P less than 0.001) and both with the environmental (Ci) concentrations (r = 0.947, n = 144, P less than 0.001; r = 0.827, n = 36, P less than 0.001). The alveolar retention of ETO (1-Ca/Ci) was equal to 75-80% of the inhaled ETO. In comparison with a blood/air partition coefficient equal in vitro to 90 (SD = 20), the mean Cb/Ca ratio found in the exposed workers was equal to 12-17. During work the blood ETO concentration was, on average, three times the environmental ETO concentration.
通过在工作班次期间及结束时检测环境空气、肺泡气和血液，对一家医院消毒设备部门的10名工人的环氧乙烷职业暴露情况进行了研究。肺泡环氧乙烷（Ca）浓度与血液（Cb）浓度相互关联（r = 0.744，n = 36，P < 0.001），且二者均与环境（Ci）浓度相关（r = 0.947，n = 144，P < 0.001；r = 0.827，n = 36，P < 0.001）。环氧乙烷的肺泡潴留率（1 - Ca/Ci）等于吸入环氧乙烷的75 - 80%。与体外血液/空气分配系数等于90（标准差 = 20）相比，暴露工人中测得的平均Cb/Ca比值等于12 - 17。工作期间，血液环氧乙烷浓度平均是环境环氧乙烷浓度的三倍。
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