Department of Adult Joint Reconstructive Surgery, Peking University Fourth School of Clinical Medicine, 31 East Xinjiekou Street, Beijing, 100035, China.
Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Arthritis Res Ther. 2023 Jul 19;25(1):120. doi: 10.1186/s13075-023-03103-w.
Neck pain (NP) is a common symptom reported in the elderly. However, no study has examined the relationship between NP and osteoarthritis (OA) so far, and this study aimed to investigate the association of neck pain with the prevalence and mortality of OA.
A total of 5965 participants were included in this cohort study based on the National Health and Nutrition Examination Survey data set of the USA (NHANES). Death outcomes follow-up information was ascertained by linkage to National Death Index (NDI). The association between NP and OA was studied by multi-various logistic regression models after adjusting for potential confounding factors. Cox proportional hazards models were used to elucidate the relationship between NP and all-cause mortality in OA patients.
Among all participants, 8.18% had osteoarthritis, and 5.92% suffered from neck pain. Neck pain was associated with osteoarthritis [1.932 (1.232, 3.028), p < 0.01], which still reminded significant after adjustments [2.519 (1.325, 4.788), p < 0.01] and stratified analysis by sex, race, and smoke status. In OA patients, chronic neck pain (over 1 year) was significantly associated with higher risks of all-cause mortality before [2.94 (1.61, 5.37), p < 0.01] and after adjustment [3.30 (1.23, 45.85), p < 0.05].
Neck pain was strongly associated with osteoarthritis. Moreover, chronic neck pain over 1 year significantly increased the mortality of OA patients. Our study demonstrates the need to screen osteoarthritis in the neck pain population and select a more appropriate treatment strategy promptly for those patients.
颈部疼痛（NP）是老年人常见的症状。然而，目前尚无研究探讨 NP 与骨关节炎（OA）之间的关系，本研究旨在调查颈部疼痛与 OA 的患病率和死亡率之间的关联。
本队列研究基于美国国家健康和营养检查调查（NHANES）的数据，共纳入 5965 名参与者。通过与国家死亡指数（NDI）的链接，确定死亡结局的随访信息。在调整潜在混杂因素后，使用多变量逻辑回归模型研究 NP 与 OA 之间的关系。Cox 比例风险模型用于阐明 NP 与 OA 患者全因死亡率之间的关系。
在所有参与者中，8.18%患有骨关节炎，5.92%患有颈部疼痛。颈部疼痛与骨关节炎相关[1.932（1.232，3.028），p<0.01]，调整后仍有显著意义[2.519（1.325，4.788），p<0.01]，且按性别、种族和吸烟状况进行分层分析。在 OA 患者中，慢性颈部疼痛（超过 1 年）与全因死亡率的风险显著增加相关，包括在调整前[2.94（1.61，5.37），p<0.01]和调整后[3.30（1.23，45.85），p<0.05]。
颈部疼痛与骨关节炎密切相关。此外，超过 1 年的慢性颈部疼痛显著增加了 OA 患者的死亡率。我们的研究表明，需要对颈部疼痛人群进行骨关节炎筛查，并为这些患者及时选择更合适的治疗策略。
