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职业性硬质合金接触致间质性肺病:两例报告

Interstitial lung disease related to occupational hard metal exposure: two case reports.

机构信息

Department of Occupational Medicine and Clinical Toxicology, Taipei Veterans General Hospital, Taipei, Taiwan.

Department of Medicine, Taipei Medical University, Taipei, Taiwan.

出版信息

J Med Case Rep. 2023 Jul 20;17(1):312. doi: 10.1186/s13256-023-04043-4.

Abstract

BACKGROUND

Hard metal lung disease (HMLD) is a relatively less known occupational interstitial lung disease, and instances of HMLD resulting from para-occupational exposure are rarely reported.

CASE PRESENTATION

This paper presents two cases of interstitial lung disease caused by exposure to hard metal. The first case involves a 37-year-old Taiwanese man who had worked at a grinder station for hard metal materials for 12 years without respiratory protective equipment. He experienced a dry cough and exertional dyspnea, and his chest imaging and pathology findings were consistent with the features of usual interstitial pneumonia. Analysis of his lung tissue revealed the presence of tungsten and cobalt. The second case involves a 68-year-old Taiwanese woman, the mother of the first patient, who had hand-washed her son's workwear. She experienced a dry cough and had similar imaging findings to her son. After her son left his job, they both exhibited improved symptoms and lung functions with nintedanib treatment. These findings suggest a diagnosis of HMLD and interstitial lung disease resulting from para-occupational exposure to hard metal dust.

CONCLUSIONS

The diagnosis of HMLD relies on obtaining a detailed occupational exposure history. If HMLD is diagnosed, discontinuing exposing to hard metal dusts can lead to improved lung function.

摘要

背景

硬金属肺病(HMLD)是一种相对不太为人知的职业性间质性肺病,因准职业性暴露而导致的 HMLD 病例很少报道。

病例介绍

本文介绍了两例因接触硬金属而导致的间质性肺病。第一例为一名 37 岁的台湾男性,他在硬金属材料研磨站工作了 12 年,没有使用呼吸防护设备。他出现干咳和活动后呼吸困难,胸部影像学和病理学表现符合寻常型间质性肺炎的特征。对其肺组织的分析显示存在钨和钴。第二例为第一位患者的 68 岁台湾女性母亲,她曾手洗儿子的工作服。她出现干咳,与儿子的影像学表现相似。在儿子离职后,他们均接受尼达尼布治疗,症状和肺功能均得到改善。这些发现提示为硬金属粉尘的准职业性暴露导致的 HMLD 和间质性肺病。

结论

HMLD 的诊断依赖于获取详细的职业暴露史。如果诊断为 HMLD,停止接触硬金属粉尘可改善肺功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2afb/10357746/fbec3a68fdc3/13256_2023_4043_Fig1_HTML.jpg

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