Yan Bing, Zhao Yang, Peng Huisheng
Institute of Flexible Electronics and Research and Development Institute of Northwestern Polytechnical University in Shenzhen, Northwestern Polytechnical University, Xi'an, 710072, China.
State Key Laboratory of Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023, China.
Small Methods. 2023 Oct;7(10):e2300501. doi: 10.1002/smtd.202300501. Epub 2023 Jul 19.
Implantable electronic devices can realize real-time and reliable health monitoring, diagnosis, and treatment of human body, which are expected to overcome important bottlenecks in the biomedical field. However, the commonly used energy supply devices for them are implantable batteries based on conventional rigid device design with toxic components, which both mechanically and biologically mismatch soft biological tissues. Therefore, the development of highly soft, safe, and implantable tissue-matchable flexible batteries is of great significance and urgency for implantable bioelectronics. In this work, the recent advances of tissue-matchable and implantable flexible batteries are overviewed, focusing on the design strategies of electrodes/batteries and their biomedical applications. The mechanical flexibility, biocompatibility, and electrochemical performance in vitro and in vivo of these flexible electrodes/batteries are then discussed. Finally, perspectives are provided on the current challenges and possible directions of this field in the future.
可植入电子设备能够实现对人体的实时、可靠的健康监测、诊断和治疗，有望克服生物医学领域的重要瓶颈。然而，它们常用的能量供应装置是基于传统刚性器件设计的植入式电池，含有有毒成分，在机械和生物学上都与柔软的生物组织不匹配。因此，开发高度柔软、安全且可植入的组织匹配性柔性电池对于可植入生物电子学具有重大意义和紧迫性。在这项工作中，综述了组织匹配性和可植入柔性电池的最新进展，重点关注电极/电池的设计策略及其生物医学应用。然后讨论了这些柔性电极/电池在体外和体内的机械柔韧性、生物相容性和电化学性能。最后，对该领域当前面临的挑战和未来可能的发展方向提出了展望。
