Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China.
Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China.
ACS Biomater Sci Eng. 2023 Aug 14;9(8):4462-4496. doi: 10.1021/acsbiomaterials.3c00399. Epub 2023 Jul 20.
The craniofacial region is composed of 23 bones, which provide crucial function in keeping the normal position of brain and eyeballs, aesthetics of the craniofacial complex, facial movements, and visual function. Given the complex geometry and architecture, craniofacial bone defects not only affect the normal craniofacial structure but also may result in severe craniofacial dysfunction. Therefore, the exploration of rapid, precise, and effective reconstruction of craniofacial bone defects is urgent. Recently, developments in advanced bone tissue engineering bring new hope for the ideal reconstruction of the craniofacial bone defects. This report, presenting a first-time comprehensive review of recent advances of biomaterials in craniofacial bone tissue engineering, overviews the modification of traditional biomaterials and development of advanced biomaterials applying to craniofacial reconstruction. Challenges and perspectives of biomaterial development in craniofacial fields are discussed in the end.
颅面区域由 23 块骨头组成，这些骨头在保持大脑和眼球的正常位置、颅面复合体的美学、面部运动和视觉功能方面起着至关重要的作用。由于颅面骨具有复杂的几何形状和结构，骨缺损不仅会影响正常的颅面结构，还可能导致严重的颅面功能障碍。因此，探索快速、精确、有效的颅面骨缺损重建是当务之急。最近，先进的骨组织工程的发展为颅面骨缺损的理想重建带来了新的希望。本报告首次全面综述了生物材料在颅面骨组织工程中的最新进展，综述了传统生物材料的改性和应用于颅面重建的先进生物材料的发展。最后讨论了生物材料在颅面领域发展所面临的挑战和展望。
