Amirazodi Maryam, Mehrabi Amin, Rajizadeh Mohammad Amin, Bejeshk Mohammad Abbas, Esmaeilpour Khadijeh, Daryanoosh Farhad, Gaeini Abbasali
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Shiraz University International Division, Shiraz University, Shiraz, Iran.
Iran J Basic Med Sci. 2022 Feb;25(2):254-262. doi: 10.22038/IJBMS.2022.57780.12853.
High-intensity interval training (HIIT) is a shape of interval training that provides ameliorated athletic capacity and has a good effect on health. Resveratrol is a natural polyphenol abundant in grapes and red wine and has been demonstrated to apply various useful health impacts on the body. This research aimed to evaluate the interactive effects of swimming HIIT and resveratrol consumption on SIRTs 3 & 4, NAD+/NADH, AMPK and SOD2 expression in aged rats.
In total, forty-five old male albino rats (Wistar) with the age of twenty months were allocated into 5 groups randomly. Control group (Ctrl), Swimming HIIT group (Ex: Exercise), Swimming HIIT with Resveratrol consumption group (R+Ex), Resveratrol consumption group (R) and solvent of resveratrol consumption group (vehicle). R+Ex group accomplished the exercise and consumed resveratrol (10 mg/kg/day, gavage) for 6 weeks.
HIIT & resveratrol significantly increased NAD+/NADH, SOD 2 and AMPK in the aged rats. HIIT increased SIRT3, but resveratrol reduced it. As for SIRT4, HIIT decreased it, while resveratrol positively affected it.
Resveratrol and HIIT, especially their combination, have anti-oxidant and anti-aging effects on the hippocampus of old rats.
高强度间歇训练（HIIT）是间歇训练的一种形式，可提高运动能力，对健康有良好影响。白藜芦醇是一种在葡萄和红酒中含量丰富的天然多酚，已被证明对身体有多种有益的健康影响。本研究旨在评估游泳HIIT和白藜芦醇摄入对老年大鼠SIRTs 3和4、NAD+/NADH、AMPK和SOD2表达的交互作用。
将45只20月龄的雄性白化Wistar大鼠随机分为5组。对照组（Ctrl）、游泳HIIT组（Ex：运动）、游泳HIIT并摄入白藜芦醇组（R+Ex）、摄入白藜芦醇组（R）和白藜芦醇溶剂组（载体）。R+Ex组进行运动并摄入白藜芦醇（10 mg/kg/天，灌胃）6周。
HIIT和白藜芦醇显著增加了老年大鼠的NAD+/NADH、SOD 2和AMPK。HIIT增加了SIRT3，但白藜芦醇降低了它。至于SIRT4，HIIT降低了它，而白藜芦醇对其有积极影响。
白藜芦醇和HIIT，尤其是它们的组合，对老年大鼠海马体具有抗氧化和抗衰老作用。
