表面张力在微型机器人穿透膜中的作用。
Role of Surface Tension in Microrobot Penetration in Membranes.
作者信息
Rahman Md Mahmudur, Garudadri Tanmay, Das Sambeeta
机构信息
Department of Mechanical Engineering, University of Delaware, Newark, DE 19716 USA. He is now with Department of Mechanical Engineering, Georgia Southern University, Statesboro, GA 30458 USA.
University of Delaware, Newark, DE 19716 USA.
出版信息
Int Conf Manip Autom Robot Small Scales. 2022 Jul;2022. doi: 10.1109/marss55884.2022.9870474. Epub 2022 Sep 2.
cell-membrane fusion using microrobots can be a useful technique for delivering bioactive compounds to cellular systems. The role of membrane curvature and lipid ordering in the cell membrane penetration process is well known. However, once the fusion into the cell membrane is already initiated, the fluid dynamics of microrobot penetration based on tension difference of the microrobot solution and membrane curvature at the fusion pore has not been explored yet. Here, we demonstrate how surface tension difference among merging interfaces plays role in microrobot droplet penetration into a liquid bath, mimicking cell membrane fusion. The maximum penetration of a microrobot droplet into a liquid bath depends on the positive difference of surface tension between the droplet and liquid bath, longitudinal curvature of the bridge region, and the size of the droplet.
使用微型机器人进行细胞膜融合可能是一种将生物活性化合物递送至细胞系统的有用技术。膜曲率和脂质有序性在细胞膜穿透过程中的作用是众所周知的。然而，一旦细胞膜融合已经启动，基于微型机器人溶液的张力差和融合孔处的膜曲率的微型机器人穿透的流体动力学尚未得到探索。在此，我们展示了合并界面之间的表面张力差如何在微型机器人液滴穿透液体浴中发挥作用，以此模拟细胞膜融合。微型机器人液滴对液体浴的最大穿透取决于液滴与液体浴之间表面张力的正差值、桥接区域的纵向曲率以及液滴的大小。
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