Department of Orthodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL, USA.
Orthod Craniofac Res. 2023 Dec;26 Suppl 1(Suppl 1):64-72. doi: 10.1111/ocr.12701. Epub 2023 Aug 1.
External apical root resorption (EARR) is a multifactorial disorder with adverse clinical outcomes in orthodontic practices often resulting in significant root shortening. This study examined the effect that specific single nucleotide polymorphisms (SNPs) have on the risk of developing EARR in orthodontic patients in X. We also evaluated how other selected patient- and treatment-related factors may contribute to root resorption in these patients.
SETTING/SAMPLE: Patients included in this case-control study were treated at the University of Alabama at Birmingham School of Dentistry, Department of Orthodontics.
Panoramic radiographs were used to measure root resorption of the maxillary incisors. EARR was recorded when at least 20% of the root length had been lost with orthodontic treatment. Factors evaluated for association with EARR included ethnicity, sex, age, dental and skeletal classifications, ANB, U1-SN, overjet, treatment type and time, and SNPs in IL-1A (rs1800587), IL-1B (rs1143634), IL-1RN (rs419598), P2RX7 (rs1718119 and rs2230912), IRAK1 (rs1059703) and CASP1 (rs530537, rs580253 and rs554344). Chi-square test, Student's t test, Wilcoxon test, Benjamin-Hochberg false discovery rate (FDR) adjustment and logistic regression were used to analyse the data. The significance level was defined as P < .05.
We found that extraction treatment protocol and dental classification displayed significant association with root resorption. Furthermore, the GG genotype of IL-1A rs1800587 variant (in individuals with an increased overjet) predisposed Caucasians to EARR. While CASP1 (rs530537) variant may contribute to the risk of root resorption, it was not statistically significant after FDR adjustment (P = .09).
Both patient- and treatment-related factors contributed to EARR.
外部根尖吸收（EARR）是一种多因素疾病，在正畸治疗中常导致严重的临床后果，导致显著的牙根缩短。本研究旨在探讨 X 染色体上特定单核苷酸多态性（SNP）对正畸患者发生 EARR 风险的影响。我们还评估了其他选定的患者和治疗相关因素如何导致这些患者的牙根吸收。
设置/样本：本病例对照研究的患者在阿拉巴马大学伯明翰分校牙科学院正畸科接受治疗。
使用全景片测量上颌切牙的牙根吸收情况。当正畸治疗导致至少 20%的牙根长度丢失时，记录 EARR。评估与 EARR 相关的因素包括种族、性别、年龄、牙颌分类、ANB、U1-SN、覆颌、治疗类型和时间以及 IL-1A(rs1800587)、IL-1B(rs1143634)、IL-1RN(rs419598)、P2RX7(rs1718119 和 rs2230912)、IRAK1(rs1059703)和 CASP1(rs530537、rs580253 和 rs554344)的 SNP。采用卡方检验、Student's t 检验、Wilcoxon 检验、Benjamini-Hochberg 假发现率（FDR）调整和逻辑回归分析数据。显著性水平定义为 P <.05。
我们发现，拔牙治疗方案和牙颌分类与牙根吸收有显著相关性。此外，IL-1A(rs1800587)变体中 GG 基因型（伴有过度覆颌的个体）使白种人易发生 EARR。虽然 CASP1(rs530537)变体可能会增加牙根吸收的风险，但在 FDR 调整后无统计学意义（P =.09）。
患者和治疗相关因素均导致 EARR。
