医院中阿米卡星使用量增加期间沙雷氏菌属中氨基糖苷类6'-N-乙酰基转移酶的频率
Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital.
作者信息
Larson T A, Garrett C R, Gerding D N
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):176-8. doi: 10.1128/AAC.30.1.176.
Abstract
The incidence of tobramycin-resistant, gentamicin-susceptible Serratia species at the Minneapolis Veterans Administration Medical Center decreased from an average 42.1 to 2.5% (P less than 0.001) during a 4.5-year period despite the predominant use of amikacin. These organisms were shown to express a 6'-N-acetyltransferase-modifying enzyme (EC 2.3.1.82). Resistance was not shown to be plasmid mediated.
摘要
在明尼阿波利斯退伍军人管理局医疗中心，尽管主要使用阿米卡星，但在4.5年的时间里，对妥布霉素耐药、对庆大霉素敏感的沙雷氏菌属的发生率从平均42.1%降至2.5%（P<0.001）。这些微生物被证明表达一种6'-N-乙酰转移酶修饰酶（EC 2.3.1.82）。耐药性并非由质粒介导。
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Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital.医院中阿米卡星使用量增加期间沙雷氏菌属中氨基糖苷类6'-N-乙酰基转移酶的频率
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Enzymatic Adenylylation of Streptomycin and Spectinomycin by R-Factor-Resistant Escherichia coli.R 因子抗性大肠杆菌对链霉素和壮观霉素的酶腺苷酰化作用。
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