编码胰多肽和神经肽Y的基因位于人类第17号和第7号染色体上。
Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
作者信息
Takeuchi T, Gumucio D L, Yamada T, Meisler M H, Minth C D, Dixon J E, Eddy R E, Shows T B
出版信息
J Clin Invest. 1986 Mar;77(3):1038-41. doi: 10.1172/JCI112357.
Pancreatic polypeptide and neuropeptide Y share 50% amino acid homology (18 out of 36 residues), suggesting that they may have common ancestral origins. cDNA clones complementary to human mRNAs encoding pancreatic polypeptide and neuropeptide Y were used to detect specific human genomic DNA sequences in human-mouse somatic cell hybrid lines. The pancreatic polypeptide gene (PPY) segregated with human chromosome 17, while the neuropeptide Y gene (NPY) segregated with human chromosome 7. Examination of cell hybrids with chromosomal rearrangements assigned PPY to the p11.1-qter region and NPY to the pter-q22 region of their respective chromosomes.
胰多肽与神经肽Y有50%的氨基酸同源性（36个残基中有18个相同），这表明它们可能有共同的祖先起源。与编码胰多肽和神经肽Y的人mRNA互补的cDNA克隆被用于检测人-鼠体细胞杂种系中的特定人类基因组DNA序列。胰多肽基因（PPY）与人类17号染色体分离，而神经肽Y基因（NPY）与人类7号染色体分离。对具有染色体重排的细胞杂种的检测将PPY定位到其相应染色体的p11.1-qter区域，将NPY定位到pter-q22区域。
Zotero 插件