Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Virol J. 2023 Aug 9;20(1):179. doi: 10.1186/s12985-023-02152-6.
SARS-CoV-2 has been responsible for the recent pandemic all over the world, which has caused many complications. One of the hallmarks of SARS-CoV-2 infection is an induced immune dysregulation, in some cases resulting in cytokine storm syndrome, acute respiratory distress syndrome and many organs such as lungs, brain, and heart that are affected during the SARS-CoV-2 infection. Several physiological parameters are altered as a result of infection and cytokine storm. Among them, microRNAs (miRNAs) might reflect this poor condition since they play a significant role in immune cellular performance including inflammatory responses. Both host and viral-encoded miRNAs are crucial for the successful infection of SARS-CoV-2. For instance, dysregulation of miRNAs that modulate multiple genes expressed in COVID-19 patients with comorbidities (e.g., type 2 diabetes, and cerebrovascular disorders) could affect the severity of the disease. Therefore, altered expression levels of circulating miRNAs might be helpful to diagnose this illness and forecast whether a COVID-19 patient could develop a severe state of the disease. Moreover, a number of miRNAs could inhibit the expression of proteins, such as ACE2, TMPRSS2, spike, and Nsp12, involved in the life cycle of SARS-CoV-2. Accordingly, miRNAs represent potential biomarkers and therapeutic targets for this devastating viral disease. In the current study, we investigated modifications in miRNA expression and their influence on COVID-19 disease recovery, which may be employed as a therapy strategy to minimize COVID-19-related disorders.
SARS-CoV-2 是导致全球近期大流行的元凶，引发了许多并发症。SARS-CoV-2 感染的特征之一是诱导免疫失调，在某些情况下会导致细胞因子风暴综合征、急性呼吸窘迫综合征以及肺部、大脑和心脏等许多器官受累。感染和细胞因子风暴会导致多种生理参数发生改变。其中，微小 RNA（miRNA）可能反映了这种不良状态，因为它们在免疫细胞功能中发挥着重要作用，包括炎症反应。宿主和病毒编码的 miRNA 对于 SARS-CoV-2 的成功感染都至关重要。例如，调节 COVID-19 合并症患者（如 2 型糖尿病和脑血管疾病）多个基因表达的 miRNA 失调可能会影响疾病的严重程度。因此，循环 miRNA 的表达水平改变可能有助于诊断这种疾病，并预测 COVID-19 患者是否会发展为严重状态。此外，许多 miRNA 可以抑制 SARS-CoV-2 生命周期中涉及的蛋白质，如 ACE2、TMPRSS2、刺突和 Nsp12 的表达。因此，miRNA 是这种破坏性病毒疾病的潜在生物标志物和治疗靶点。在本研究中，我们研究了 miRNA 表达的变化及其对 COVID-19 疾病恢复的影响，这可能被用作一种治疗策略，以最小化与 COVID-19 相关的疾病。
