School of Petrochemical Engineering & Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu, Lanzhou University of Technology, Lanzhou, 730050, China.
State Key Laboratory of Veterinary Etiological Biology and Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China.
J Fluoresc. 2024 Jul;34(4):1603-1615. doi: 10.1007/s10895-023-03357-2. Epub 2023 Aug 10.
Widely utilized in the chemical industry and agriculture, hydrazine is easily absorbed by living things and can cause physical harm when in touch for an extended period of time. As a result, a novel cinnamaldehyde chalcone C5 was produced by Friedel Crafts process and aldol condensation reaction. Triphenylamine was used as the raw material for hydrazine determination in both reactions. Chalcone C5 exhibits significant AIE behavior in a mixed mixture of ethanol and water in addition to having great selectivity and a low detection limit (0.119 nm) for hydrazine. The solvent effect test revealed a linear relationship between the Stokes shift of C5 in the solvent and the rise in solvent orientation polarization. It is important to note that C5 is not harmful to MCF-7 cells, mouse kidney cells, or pig kidney cells. Furthermore, research on cell imaging has demonstrated that probe C5 may be utilized to image the fluorescence of hydrazine in active MCF-7 cells.
肼广泛应用于化学工业和农业，易被生物吸收，长时间接触会造成身体伤害。因此，通过傅克反应和羟醛缩合反应，制备了一种新型肉桂醛查尔酮 C5。在这两个反应中，三苯胺都被用作肼测定的原料。查尔酮 C5 在乙醇和水的混合溶液中表现出显著的聚集诱导发光行为，对肼具有高选择性和低检测限（0.119nm）。溶剂效应测试表明，C5 在溶剂中的斯托克斯位移与溶剂取向极化的增加呈线性关系。需要注意的是，C5 对 MCF-7 细胞、小鼠肾细胞或猪肾细胞没有毒性。此外，细胞成像研究表明，探针 C5 可用于对活 MCF-7 细胞中肼的荧光进行成像。
