Wang Hao, Feng Yanfei, Zheng Xiangyi, Xu Xin
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Cancers (Basel). 2023 Feb 4;15(4):1007. doi: 10.3390/cancers15041007.
Bladder cancer is one of the most common malignancies of the urinary tract and can be divided into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Although the means of diagnosis and treatment have continually improved in recent years, the recurrence rate of bladder cancer remains high, and patients with MIBC typically have an unfavourable prognosis and a low quality of life. Emerging evidence demonstrates that long noncoding RNAs play a crucial role in the carcinogenesis and progression of bladder cancer. Long intergenic noncoding RNAs (lincRNAs) are a subgroup of long noncoding RNAs (lncRNAs) that do not overlap protein-coding genes. The potential role of lincRNAs in the regulation of gene expression has been explored in depth in recent years. Small nucleolar RNAs (snoRNAs) are a class of noncoding RNAs (ncRNAs) that mainly exist in the nucleolus, are approximately 60-300 nucleotides in length, and are hosted inside the introns of genes. Small nucleolar RNA host genes (SNHGs) have been associated with the origin and development of bladder cancer. In this review, we aim to comprehensively summarize the biological functions of these molecules in bladder cancer.
膀胱癌是最常见的泌尿系统恶性肿瘤之一，可分为非肌层浸润性膀胱癌（NMIBC）和肌层浸润性膀胱癌（MIBC）。尽管近年来诊断和治疗手段不断改进，但膀胱癌的复发率仍然很高，MIBC患者通常预后不良且生活质量较低。新出现的证据表明，长链非编码RNA在膀胱癌的发生和发展中起关键作用。长链基因间非编码RNA（lincRNA）是长链非编码RNA（lncRNA）的一个亚组，不与蛋白质编码基因重叠。近年来，lincRNA在基因表达调控中的潜在作用已得到深入研究。小核仁RNA（snoRNA）是一类主要存在于核仁中的非编码RNA（ncRNA），长度约为60-300个核苷酸，位于基因的内含子内。小核仁RNA宿主基因（SNHG）与膀胱癌的发生和发展有关。在这篇综述中，我们旨在全面总结这些分子在膀胱癌中的生物学功能。
