Price M F, Gentry L O
Eur J Clin Microbiol. 1986 Aug;5(4):416-9. doi: 10.1007/BF02075697.
A latex agglutination test which detects candida antigen in patients with disseminated infection was used to screen 328 patients. Of these patients 100 had renal failure but no signs or symptoms of candida infection, and 100 had high rheumatoid factor titers but also no signs or symptoms of candida infection. The remaining 128 patients were considered at high risk of developing systemic candida infection. Sequential titers were also determined in a number of these patients. The incidence of candida antigen titers greater than or equal to 1:4 in the low-risk population was 3% as compared to 53% in the high-risk group. None of the patients with positive rheumatoid factor titers had candida antigen titers greater than or equal to 1:2, however 13% had nonspecific agglutination at titers greater than 1:2. The incidence of nonspecific agglutination increased with increasing rheumatoid factor titers. In general the candida antigen titers correlated well with clinical findings and with the course of infection in those patients in whom sequential candida antigen titers were determined. This latex test thus appears to be a useful adjunct procedure for the diagnosis of serious candida infections.
一种用于检测播散性感染患者念珠菌抗原的乳胶凝集试验被用于筛查328名患者。在这些患者中，100人有肾衰竭但无念珠菌感染的体征或症状，100人类风湿因子滴度高但也无念珠菌感染的体征或症状。其余128名患者被认为有发生系统性念珠菌感染的高风险。还对其中一些患者进行了连续滴度测定。低风险人群中念珠菌抗原滴度大于或等于1:4的发生率为3%，而高风险组为53%。类风湿因子滴度阳性的患者中，没有念珠菌抗原滴度大于或等于1:2的，但13%的患者在滴度大于1:2时有非特异性凝集。非特异性凝集的发生率随着类风湿因子滴度的升高而增加。总体而言，念珠菌抗原滴度与临床发现以及在那些进行了连续念珠菌抗原滴度测定的患者的感染病程相关性良好。因此，这种乳胶试验似乎是诊断严重念珠菌感染的一种有用的辅助方法。
