Wang Yifan, Xu Yingde, Zhang Xuefeng, Liu Jingyu, Han Jintong, Zhu Shengli, Liang Yanqin, Wu Shuilin, Cui Zhenduo, Lü Weijia, Li Zhaoyang
Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, 300350, P. R. China.
Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences, Shenzhen Guangdong, 518055, P. R. China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Aug 15;37(8):937-944. doi: 10.7507/1002-1892.202303041.
To design and construct a graphene oxide (GO)/silver nitrate (AgPO)/chitosan (CS) composite coating for rapidly killing bacteria and preventing postoperative infection in implant surgery.
GO/AgPO composites were prepared by ion exchange method, and CS and GO/AgPO composites were deposited on medical titanium (Ti) sheets successively. The morphology, physical image, photothermal and photocatalytic ability, antibacterial ability, and adhesion to the matrix of the materials were characterized.
The GO/AgPO composites were successfully prepared by ion exchange method and the heterogeneous structure of GO/AgPO was proved by morphology phase test. The heterogeneous structure formed by AgPO and GO reduced the band gap from 1.79 eV to 1.39 eV which could be excited by 808 nm near-infrared light. The photothermal and photocatalytic experiments proved that the GO/AgPO/CS coating had excellent photothermal and photodynamic properties. antibacterial experiments showed that the antibacterial rate of the GO/AgPO/CS composite coating against reached 99.81% after 20 minutes irradiation with 808 nm near-infrared light. At the same time, the composite coating had excellent light stability, which could provide stable and sustained antibacterial effect.
GO/AgPO/CS coating can be excited by 808 nm near infrared light to produce reactive oxygen species, which has excellent antibacterial activity under light.
设计并构建一种氧化石墨烯（GO）/硝酸银（AgPO）/壳聚糖（CS）复合涂层，用于在植入手术中快速杀灭细菌并预防术后感染。
采用离子交换法制备GO/AgPO复合材料，并将CS和GO/AgPO复合材料依次沉积在医用钛（Ti）片上。对材料的形貌、物理图像、光热和光催化能力、抗菌能力以及与基体的附着力进行表征。
通过离子交换法成功制备了GO/AgPO复合材料，形貌相测试证明了GO/AgPO的异质结构。AgPO与GO形成的异质结构使带隙从1.79 eV降低到1.39 eV，可被808 nm近红外光激发。光热和光催化实验证明GO/AgPO/CS涂层具有优异的光热和光动力性能。抗菌实验表明，808 nm近红外光照射20分钟后，GO/AgPO/CS复合涂层对 的抗菌率达到99.81%。同时，复合涂层具有优异的光稳定性，可提供稳定持续的抗菌效果。
GO/AgPO/CS涂层可被808 nm近红外光激发产生活性氧，在光照下具有优异的抗菌活性。
