[非编码RNA对骨H型血管生成的调控]
[Regulation of non-coding RNA in type H vessels angiogenesis of bone].
作者信息
Tang Shengping, Liao Shijie, Liu Jianhong, Luo Xiaolin, Wei Zhendi, Ding Xiaofei
机构信息
Department of Trauma Orthopedic and Hand Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021, P. R. China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Aug 15;37(8):1042-1048. doi: 10.7507/1002-1892.202304032.
OBJECTIVE
To summarize the regulatory effect of non-coding RNA (ncRNA) on type H vessels angiogenesis of bone.
METHODS
Recent domestic and foreign related literature about the regulation of ncRNA in type H vessels angiogenesis was widely reviewed and summarized.
RESULTS
Type H vessels is a special subtype of bone vessels with the ability to couple bone formation. At present, the research on ncRNA regulating type H vessels angiogenesis in bone diseases mainly focuses on microRNA, long ncRNA, and small interfering RNA, which can affect the expressions of hypoxia inducible factor 1α, platelet derived growth factor BB, slit guidance ligand 3, and other factors through their own unique ways of action, thus regulating type H vessels angiogenesis and participating in the occurrence and development of bone diseases.
CONCLUSION
At present, the mechanism of ncRNA regulating bone type H vessels angiogenesis has been preliminarily explored. With the deepening of research, ncRNA is expected to be a new target for the diagnosis and treatment of vascular related bone diseases.
目的
总结非编码RNA（ncRNA）对骨H型血管生成的调控作用。
方法
广泛查阅并总结近期国内外有关ncRNA对H型血管生成调控的相关文献。
结果
H型血管是骨血管的一种特殊亚型，具有耦联骨形成的能力。目前，关于ncRNA在骨疾病中调控H型血管生成的研究主要集中于微小RNA、长链ncRNA和小干扰RNA，它们可通过自身独特的作用方式影响缺氧诱导因子1α、血小板衍生生长因子BB、缝隙引导配体3等因子的表达，从而调控H型血管生成并参与骨疾病的发生发展。
结论
目前，ncRNA调控骨H型血管生成的机制已得到初步探索。随着研究的深入，ncRNA有望成为血管相关性骨疾病诊断和治疗的新靶点。
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