Willmott Thomas, Campbell Paul M, Griffiths Christopher E M, O'Connor Clare, Bell Michael, Watson Rachel E B, McBain Andrew J, Langton Abigail K
School of Health Sciences, The University of Manchester, Manchester, United Kingdom.
Centre for Dermatology Research, Manchester Academic Health Science Centre, The University of Manchester and Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
Front Aging. 2023 Aug 8;4:1217635. doi: 10.3389/fragi.2023.1217635. eCollection 2023.
The skin microbiota plays a crucial role in maintaining epidermal homeostasis. Ultraviolet radiation (UVR) and other environmental challenges can impact the skin microbiota through direct and indirect mechanisms. This study aimed to investigate the effects of sun exposure on the skin microbiota and its relationship with individual skin phototypes. Healthy volunteers ( = 21 [4M, 17 F], mean age 33.2 years) holidayed in a sunny destination for a minimum of 7 days with swabs taken pre-holiday and up to 84 days post-holiday. Participant group was categorised by individual typology angle (ITA) classification and the composition of the skin microbiota was examined using 16S rRNA gene sequencing. In the entire cohort and at all time points, the major bacterial phyla were Actinobacteria, Proteobacteria and Firmicutes. There was a significant change in microbial beta diversity at day 28 post-holiday, compared to baseline, for all participants. However, when participants were segregated into three cohorts dependent on the degree of skin tanning response between baseline (pre-holiday) and immediately one-day post-holiday, there was a reduction in Proteobacteria in the sun-seeking participants 1 day after the holiday, which recovered over time. These findings suggest that sun exposure can affect the diversity and composition of the skin microbiota, which may have downstream effects on skin health.
皮肤微生物群在维持表皮内环境稳定方面发挥着关键作用。紫外线辐射（UVR）和其他环境挑战可通过直接和间接机制影响皮肤微生物群。本研究旨在调查阳光照射对皮肤微生物群的影响及其与个体皮肤光类型的关系。健康志愿者（ = 21[4名男性，17名女性]，平均年龄33.2岁）在阳光充足的目的地度假至少7天，在度假前和度假后长达84天进行拭子采集。参与者组根据个体类型角度（ITA）分类进行分类，并使用16S rRNA基因测序检查皮肤微生物群的组成。在整个队列和所有时间点，主要细菌门为放线菌门、变形菌门和厚壁菌门。与基线相比，所有参与者在度假后第28天微生物β多样性有显著变化。然而，当根据基线（度假前）和度假后立即一天之间的皮肤晒黑反应程度将参与者分为三个队列时，在寻求阳光的参与者中，度假后1天变形菌门减少，随时间恢复。这些发现表明，阳光照射会影响皮肤微生物群的多样性和组成，这可能对皮肤健康产生下游影响。
