Suepaul Sharianne, Stegger Marc, Boyen Filip, Georges Karla, Butaye Patrick
Department of Pathobiology, School of Veterinary Medicine, St. George's University, True Blue, St. George's FZ818, Grenada.
Department of Basic Veterinary Sciences, School of Veterinary Medicine, Faculty of Medical Sciences, The University of the West Indies, St. Augustine 685509, Trinidad and Tobago.
Antibiotics (Basel). 2023 Jul 31;12(8):1266. doi: 10.3390/antibiotics12081266.
is an opportunistic pathogen that is frequently isolated from canines. It is of escalating interest because of its increasing antimicrobial resistance and zoonotic potential. Although many published articles are available that describe isolates obtained from diseased dogs and humans, this study focused on isolates obtained from healthy dogs and their owners who presented at clinics for routine veterinary care and utilized whole genome sequencing-based analyses for strain comparisons. A total of 25 humans and 27 canines were sampled at multiple sites, yielding 47 and 45 isolates, respectively. Whole genome sequence analysis was performed. We detected mostly new sequence types (STs) and a high diversity. Strains carried few antimicrobial resistance genes and plasmids, albeit three MRSP strains were found that belonged to two internationally distributed STs. The virulence content did not provide insights toward a tendency to colonization of humans but supported that there may be differences in the surface proteins between carrier strains and those causing pyoderma. We identified 13 cases in which humans were infected with strains from the dog they owned.
是一种机会致病菌，经常从犬类中分离出来。由于其日益增加的抗菌药物耐药性和人畜共患病潜力，它受到越来越多的关注。尽管有许多已发表的文章描述了从患病犬和人类中分离出的菌株，但本研究重点关注从前来诊所进行常规兽医护理的健康犬及其主人身上分离出的菌株，并利用基于全基因组测序的分析进行菌株比较。总共在多个部位对25名人类和27只犬进行了采样，分别获得了47株和45株菌株。进行了全基因组序列分析。我们检测到的大多是新的序列类型（STs）且具有高度多样性。菌株携带的抗菌药物耐药基因和质粒很少，不过发现了三株属于两种国际分布STs的耐甲氧西林金黄色葡萄球菌（MRSP）菌株。毒力成分并未揭示出对人类定植倾向的见解，但支持了携带菌株与引起脓皮病的菌株之间表面蛋白可能存在差异。我们确定了13例人类感染其所拥有犬只菌株的病例。
