Wegener Alice, Duim Birgitta, van der Graaf-van Bloois Linda, Zomer Aldert L, Visser Caroline E, Spaninks Mirlin, Timmerman Arjen J, Wagenaar Jaap A, Broens Els M
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Department of Medical Microbiology & Infection Prevention, Amsterdam UMC Location AMC, Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Pathogens. 2022 Jul 28;11(8):850. doi: 10.3390/pathogens11080850.
can be transmitted between dogs and their owners and can cause opportunistic infections in humans. Whole genome sequencing was applied to identify the relatedness between isolates from human infections and isolates from dogs in the same households. Genome SNP diversity and distribution of plasmids and antimicrobial resistance genes identified related and unrelated isolates in both households. Our study shows that within-host bacterial diversity is present in , demonstrating that multiple isolates from each host should preferably be sequenced to study transmission dynamics.
可在狗及其主人之间传播，并可导致人类机会性感染。应用全基因组测序来确定人类感染分离株与同家庭中狗的分离株之间的相关性。基因组单核苷酸多态性多样性以及质粒和抗菌抗性基因的分布确定了两个家庭中相关和不相关的分离株。我们的研究表明，宿主内存在细菌多样性，这表明每个宿主的多个分离株最好进行测序以研究传播动态。
