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黄酮醇提取物的抗自由基及免疫调节活性分析

Flavonol Extract-Antiradical and Immunomodulating Activities Analysis.

作者信息

Bushmeleva Kseniya, Vyshtakalyuk Alexandra, Terenzhev Dmitriy, Belov Timur, Nikitin Evgeniy, Zobov Vladimir

机构信息

A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str. 8, Kazan 420088, Russia.

出版信息

Plants (Basel). 2023 Aug 17;12(16):2976. doi: 10.3390/plants12162976.

DOI:10.3390/plants12162976
PMID:37631187
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10458422/
Abstract

The study of () biological activity is focused on obtaining the crude extract and separation of the flavonol compounds. The extraction and fractionation of fruits, followed by quantitative analysis, were accomplished using high-performance liquid chromatography and Darco G-60 filtering. This approach enabled the quantification of flavonoids within each fraction. The antioxidative, immunomodulating activities and cytotoxicity with respect to the lymphoblast cell line RPMI-1788 were studied. The flavonol extract of has been shown to have a high capacity to neutralize free DPPH and AAPH radicals in vitro. It also caused an accelerated 'respiratory burst' formation of neutrophils and an increase in the metabolic reserves of cells in rats exposed to cyclophosphamide. The reference solution (an equivalent quercetin-rutin blend) contributed to a decrease in lipid peroxidation, intensifying phagocytosis processes. The studied compounds demonstrated their low influence on the leukocyte blood profile in animals.

摘要

对（）生物活性的研究集中于获得粗提物并分离黄酮醇化合物。使用高效液相色谱法和Darco G - 60过滤法完成了对果实的提取、分馏及定量分析。这种方法能够对每个馏分中的黄酮类化合物进行定量。研究了其对淋巴细胞系RPMI - 1788的抗氧化、免疫调节活性和细胞毒性。已表明（）的黄酮醇提取物在体外具有高能力中和游离的DPPH和AAPH自由基。它还使暴露于环磷酰胺的大鼠中性粒细胞加速形成“呼吸爆发”并增加细胞的代谢储备。参比溶液（等量槲皮素 - 芦丁混合物）有助于减少脂质过氧化，增强吞噬过程。所研究的化合物对动物白细胞血液谱的影响较小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/2c4604e2622c/plants-12-02976-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/fbd8a2bd8af7/plants-12-02976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/36bd8e45a4ef/plants-12-02976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/05792b2fc82f/plants-12-02976-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/1b31f1287a41/plants-12-02976-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/19aea4eb19c1/plants-12-02976-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/e838072a832f/plants-12-02976-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/d1d41867f4c3/plants-12-02976-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/e2518cec55a0/plants-12-02976-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/2c4604e2622c/plants-12-02976-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/fbd8a2bd8af7/plants-12-02976-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/36bd8e45a4ef/plants-12-02976-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/05792b2fc82f/plants-12-02976-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/1b31f1287a41/plants-12-02976-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/19aea4eb19c1/plants-12-02976-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/e838072a832f/plants-12-02976-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/d1d41867f4c3/plants-12-02976-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/e2518cec55a0/plants-12-02976-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66aa/10458422/2c4604e2622c/plants-12-02976-g009.jpg

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