用于组织工程和再生医学的源自硬腭黏膜的生物材料。
Biomaterials derived from hard palate mucosa for tissue engineering and regenerative medicine.
作者信息
Ren Lingfei, Jiang Zhiwei, Zhang Hui, Chen Yani, Zhu Danji, He Jin, Chen Yunxuan, Wang Ying, Yang Guoli
机构信息
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
出版信息
Mater Today Bio. 2023 Aug 5;22:100734. doi: 10.1016/j.mtbio.2023.100734. eCollection 2023 Oct.
Autologous materials have superior biosafety and are widely used in clinical practice. Due to its excellent trauma-healing ability, the hard palate mucosa (HPM) has become a hot spot for autologous donor area research. Multiple studies have conducted an in-depth analysis of the healing ability of the HPM at the cellular and molecular levels. In addition, the HPM has good maneuverability as a donor area for soft tissue grafts, and researchers have isolated various specific mesenchymal stem cells (MSCs) from HPM. Free soft tissue grafts obtained from the HPM have been widely used in the clinic and have played an essential role in dentistry, eyelid reconstruction, and the repair of other specific soft tissue defects. This article reviews the advantages of HPM as a donor area and its related mechanisms, classes of HPM-derived biomaterials, the current status of clinical applications, challenges, and future development directions.
自体材料具有卓越的生物安全性，在临床实践中得到广泛应用。由于硬腭黏膜（HPM）具有出色的创伤愈合能力，已成为自体供区研究的热点。多项研究在细胞和分子水平上对HPM的愈合能力进行了深入分析。此外，HPM作为软组织移植的供区具有良好的可操作性，研究人员已从HPM中分离出各种特定的间充质干细胞（MSCs）。从HPM获取的游离软组织移植物已在临床上广泛应用，并在牙科、眼睑重建及其他特定软组织缺损的修复中发挥了重要作用。本文综述了HPM作为供区的优势及其相关机制、HPM衍生生物材料的类别、临床应用现状、挑战及未来发展方向。
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