Department of Agriculture and Horticulture, Province of Jambi, Jambi, 36122, Indonesia.
Animal Health Vocational Program, Jambi University, Muaro Jambi, 36361, Indonesia.
Vet Res Commun. 2024 Feb;48(1):225-244. doi: 10.1007/s11259-023-10199-7. Epub 2023 Aug 29.
Aflatoxin contamination in feed is a common problem in broiler chickens. The present systematic review and meta-analysis examined the impact of aflatoxin-contaminated feed and the efficacy of various feed additives on the production performance of broiler chickens fed aflatoxin-contaminated feed (AF-feed). A total of 35 studies comprising 53 AF-feed experiments were selected following PRISMA guidelines. Feed additives included in the analyses were toxins binder (TB), mannan-oligosaccharides (MOS), organic acid (OA), probiotics (PRO), protein supplementation (PROT), phytobiotics (PHY), and additive mixture (MIX). Random effects model and a frequentist network meta-analysis (NMA) were performed to rank the efficacy of feed additives, reported as standardized means difference (SMD) at 95% confidence intervals (95% CI). Overall, broiler chickens fed AF-feed had significantly lower final body weight (BW) (SMD = 198; 95% CI = 198 to 238) and higher feed conversion ratio (SMD = 0.17; 95% CI = 0.13 to 0.21) than control. Treatments with TB, MOS, and PHY improved the BW of birds fed AF-feed (P < 0.05) to be comparable with non-contaminated feed or control. Predictions on final BW from the broiler-fed aflatoxin-contaminated diet were 15% lower than the control diet. Including feed additives in the aflatoxins diet could ameliorate the depressive effect. Remarkably, our network meta-analysis highlighted that TB was the highest-performing additive (P-score = 0.797) to remedy aflatoxicosis. Altogether, several additives, especially TB, are promising to ameliorate aflatoxicosis in broiler chickens, although the efficacy was low regarding the severity of the aflatoxicosis.
饲料中的黄曲霉毒素污染是肉鸡的一个常见问题。本系统评价和荟萃分析检查了受黄曲霉毒素污染的饲料对摄入受黄曲霉毒素污染的饲料（AF-饲料）的肉鸡生产性能的影响，以及各种饲料添加剂的功效。根据 PRISMA 指南，共选择了 35 项研究，其中包含 53 项 AF-饲料实验。分析中包含的饲料添加剂有：毒素结合剂（TB）、甘露寡糖（MOS）、有机酸（OA）、益生菌（PRO）、蛋白质补充剂（PROT）、植物提取物（PHY）和添加剂混合物（MIX）。采用随机效应模型和频率网络荟萃分析（NMA）对饲料添加剂的功效进行排名，以 95%置信区间（95%CI）的标准化均数差（SMD）表示。总体而言，摄入 AF-饲料的肉鸡体重（BW）明显较低（SMD=198；95%CI=198 至 238），饲料转化率较高（SMD=0.17；95%CI=0.13 至 0.21），而对照组则相反。TB、MOS 和 PHY 的处理可改善摄入 AF-饲料的鸟类的 BW，使其与未污染的饲料或对照组相媲美（P<0.05）。从受黄曲霉毒素污染的肉鸡日粮中预测最终 BW 比对照组低 15%。在含黄曲霉毒素的日粮中添加饲料添加剂可以减轻其抑郁作用。值得注意的是，我们的网络荟萃分析突出表明 TB 是修复黄曲霉毒素中毒的表现最好的添加剂（P 评分=0.797）。总的来说，几种添加剂，特别是 TB，有望改善肉鸡的黄曲霉毒素中毒，但鉴于黄曲霉毒素中毒的严重程度，其功效较低。
