Moroff G, George V M, Siegl A M, Luban N L
Transfusion. 1986 Sep-Oct;26(5):453-6. doi: 10.1046/j.1537-2995.1986.26587020124.x.
Platelet concentrates intended for transfusion to immunosuppressed patients are irradiated to minimize transfusion-induced graft-versus-host disease. Because few reports describe how irradiation influences stored platelets, the authors studied whether 5000 rad of gamma irradiation, the maximum dose currently used clinically, altered platelets in vitro. Platelet concentrates were stored for either 1 day or 5 days in plastic (PL 732) containers before gamma irradiation. One unit of a pair of identical platelet concentrates was irradiated; the second unit served as a control. Irradiation did not alter platelet morphology, mean platelet volume, expression of platelet-factor-3 activity, response to hypotonic stress, extent of discharge of lactate dehydrogenase, release of beta-thromboglobulin, formation of thromboxane B2, nor the ability to undergo synergistic aggregation. The lack of any substantial change was observed whether the platelet concentrates were stored initially for either 1 day or 5 days. These results suggest that stored platelets are not altered deleteriously by irradiation with 5000 rad.
用于输注给免疫抑制患者的血小板浓缩物需进行辐照，以尽量减少输血诱导的移植物抗宿主病。由于很少有报告描述辐照如何影响储存的血小板，因此作者研究了目前临床上使用的最大剂量5000拉德的γ射线辐照是否会在体外改变血小板。血小板浓缩物在γ射线辐照前于塑料（PL 732）容器中储存1天或5天。一对相同的血小板浓缩物中的一个单位进行辐照；另一个单位作为对照。辐照并未改变血小板形态、平均血小板体积、血小板因子3活性的表达、对低渗应激的反应、乳酸脱氢酶的释放程度、β-血小板球蛋白的释放、血栓素B2的形成，也未改变协同聚集的能力。无论血小板浓缩物最初储存1天还是5天，均未观察到任何实质性变化。这些结果表明，5000拉德的辐照不会对储存的血小板造成有害改变。
